I wear them all of the time and have not a problem with using them with multiple or single monitor computers. The first time I ever put them on there was about 30 seconds of disorientation until I go used to them. You also need to be sure to use the right frames.
However there are people where I work who can not wear any type of bifocals so they use 2 different glasses. They have tried progressive and traditional bifocals in various combinations of frames but still are unable to use them.