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+ - Michael J. Fox Donates $2M USD to a Finnish Medicine Company

Submitted by jones_supa
jones_supa (887896) writes "Biotie Therapies from Turku, Finland has signed a USD 2 million research contract with The Michael J. Fox Foundation (MJFF) to investigate SYN120 in Parkinson's disease patients with dementia. SYN120 is a dual antagonist of 5-HT6 and 5-HT2a receptors and these two distinct modes of action could result in a unique therapeutic profile for SYN120 combining pro-cognitive and antipsychotic activities. MJFF will fund an 80 patient, Phase 2a, randomized, double-blind, placebo-controlled trial of 16 weeks duration in patients with Parkinson's disease dementia. In addition to assessing safety and tolerability, the main focus of the trial will be to establish efficacy of SYN120 on cognition using the Cognitive Drug Research (CDR) Computerized Cognition Battery as the primary efficacy endpoint. This trial, which is expected to begin in H2 2014, will be conducted by the Parkinson Study Group (PSG) at approximately 10 US sites specializing in cognitive dysfunction in Parkinson's disease."

Comment: Re:Natural vs randomized experiments (Score 1) 219

by fey000 (#47349407) Attached to: Facebook's Emotion Experiment: Too Far, Or Social Network Norm?

The fact that Facebook seems to be genuinely surprised by this response tells me everything I need to know about how they regard their users. They see them the same way an entomologist sees bugs - something to be cataloged and experimented on but not worthy of the respect one normally gives other human beings.

And how can this surprise you? Have you ever heard anything at all about Facebook respecting the privacy of its users? In fact, again and again and again Facebook ends up in the news with an anti-privacy scandal on its hands.

I am not saying that running social experiments on random people is a great idea (though it is funny), I am saying this is a 'no biggie' because it is neither surprising nor out of line with previous actions. That doesn't make it right, but anyone with half a brain should have seen it coming five years ago, and stopped using social media platforms 4 years ago. The only people who need to have these accounts are the marketeers. The rest will get much better 'social' results using 1) a phone and 2) mouth + ears.

I suppose since Facebook is owned and run by an immature child billionaire that I shouldn't be surprised.

And yet you appear to be. Facebook is run by a greedy thief, and you expect non-greedy-thief behavior. That is inconsistent.

Comment: Re:More proof failbook is for fucktarded sheeple (Score 1) 219

by fey000 (#47349271) Attached to: Facebook's Emotion Experiment: Too Far, Or Social Network Norm?

Failbook has always proved and will always prove to be intrusive. Yet the sheep that use failbook continue to prove they are nothing more than stuipid little fucks that value nothing at all. Now with this "emotion experiment" the dumb asspie cracker Zuckerberg feels he is beyond any and all laws with his sheep still saying "fuck me in the ass harder Mark." The solution to this simple, shut failbook down. If you must keep in touch that is what email and *gasp* letters via snail fucking mail is for. Then there are also a new fangdangled method called a "website" that will allow for someone to put their shit up. Making a webpage is all too simple. If they can't make one then they are too fucking stupid to even exist let alone use a fucking computer so it is best to let the fucktarded sheeple that use failbook to fucking self destruct and perhaps earn themselves a fucking darwin award along the way.

I dare say I smell the distinct aroma of a Pulitzer from your florid loquaciousness.

+ - CEOs who make outragous pecentages of company revenues->

Submitted by bizwriter
bizwriter (1064470) writes "Top earning Charif Souki of Cheniere Energy had a compensation package last year of almost $142 million, even as company revenue was $267 million with a loss of $554 million. His pay package was more than half company revenue. It turns out that hundreds of companies devote 1 percent or more — sometimes a lot more — of their revenue to pay their CEOs, including heads of such tech companies as Zynga, Splunk, TripAdvisor, Progress Software, and zulily."
Link to Original Source

+ - David "The Hoff" Hasselhoff to Star in Indie Game Megamagic

Submitted by SlappingOysters
SlappingOysters (1344355) writes "From pulling the babes in Baywatch to getting cup-caked by Adam Sandler in Clicker, David "The Hoff" Hasselhoff never fails to own a screen. Grab It has just revealed that he is bringing his magnetic presence — voice and motion-capture — to the upcoming indie game Megamagic (PC, iOS, Wii U) by BeautiFun Games. The game is described as being a mix of Zelda, Command & Conquer, Pokémon and Streets of Rage. Grab It recently released a special edition of its Grab It Game Discovery app focused on BeautiFun's first title, the classic philosophical puzzle platformer Nihilumbra."

+ - New study suggests patent trolls really are killing startups-> 1

Submitted by mpicpp
mpicpp (3454017) writes "Heavy patent litigation scared off about $22 billion in VC funding over 5 years.

Patent reform advocates have long argued that "patent trolls"—companies that do nothing but sue over patents—are harmful to innovation, not just a plague on big companies. A new study attempted to find out if there's any real data behind that accusation or if it's just a few sad anecdotes.

Turns out there is a very real, and very negative, correlation between patent troll lawsuits and the venture capital funding that startups rely on. A just-released study [PDF] by Catherine Tucker, a professor of marketing at MIT's Sloan School of Business, finds that over the last five years, VC investment "would have likely been $21.772 billion higher... but for litigation brought by frequent litigators."

The study defines "frequent litigators" as companies that file 20 or more patent lawsuits, which limits the definition to true-blue "patent trolls," or Patent Assertion Entities (PAEs), the term used by the paper. The study covers the period from 1995 to 2012.

Tucker's paper estimates a 95 percent confidence interval for the amount of lost investment to be between $8.1 billion and $41.8 billion. Those numbers are relative to a baseline of just under $131 billion of investment that actually occurred during that five-year period time."

Link to Original Source

+ - $3000 GeForce GTX TITAN Z Tested, Less Perf than $1500 R9 295X2->

Submitted by Vigile
Vigile (99919) writes "NVIDIA announced its latest dual-GPU flagship card, the GeForce GTX Titan Z, at the GPU Technology Conference in late March with a staggering price point of $2999. Since that time, AMD announced and released the Radeon R9 295X2, its own dual-GPU card with a price tag of $1499. PC Perspective finally put the GTX Titan Z to the test and found that from a PC gamers view, the card is way overpriced for the performance it offers. At both 2560x1440 and 3840x2160 (4K) the R9 295X2 offered higher and more consistent frame rates sometimes by as much as 30%. The AMD card also only takes up two slots (though it does have a water cooling radiator to worry about) while the NVIDIA GTX Titan Z is a three-slot design. The Titan Z is quieter and uses much less power, but gamers considering a $1500 or $3000 graphics card selection are likely not overly concerned with power efficiency."
Link to Original Source

Comment: Re:War of government against people? (Score 1) 875

by fey000 (#47201677) Attached to: America 'Has Become a War Zone'

But while a correlation does not prove cause-and-effect, a lack of correlation -- or more properly, a negative correlation -- can DISprove cause-and-effect.

Only in a closed system, unless you presume to have knowledge of the grand unifying theorem, and can thus explain every action in the universe.

Example: something -- all evidence points to one animal -- has been killing your chickens. You suspect the neighbor's dog. So you start keeping tabs on when the dog is let out, and when it is in the house. It turns out, after examination, that whatever it is has been killing your chickens when the dog was locked up in the house. There is no dispute... it is indisputable that the dog wasn't there when the chickens died. This negative correlation between the dog being out and dead chickens has DISproved your theory that the dog was killing the chickens.

Or, which is the recurring problem of the debate, there are two dogs, meaning that while your specific dog didn't kill the chickens, the biological family dog (Canis I believe) is responsible for the increased chicken mortality in the area. This is actually the same example as you first provide, with the rum and minister, except you have obfuscated the scenario.

It gets a bit more complicated when the numbers go up but the same principle still holds. If your theory is that X causes Y, and you find a negative correlation, for example X goes up while Y goes down, you have DISproved that X causes Y. Otherwise, barring other outside influences, you would have (no dispute) observed that Y went up as X went up. Anything else contradicts your theory.

I like how "barring other outside influences" is mentioned only in passing here, while it is considered the key disrupting factor in scientific statistical analysis, something a lot of very smart people spend a lot of time on accounting for and avoiding.
And X going up with Y going down only works when X is the entire environment. If X is merely a part of the environment (as in both of your examples) it proves that X is 1: negatively correlated to Y, or 2: X is not correlated to Y but something(s) else is, or 3: X is correlated to Y while something else is stronger negatively correlated to Y. Given that these three points can be proven without any analysis, it does not seem the statistical addition shed much light on the facts.

And in the gun-control debate, we have in fact had ample time and opportunity to control for other factors. And it is extremely important to note that try as we might, we have found no other causal factors that apply to the situation. Yet even so, as X (per-capita gun ownership and frequency of carry) has gone up, Y (violent crime of all sorts) has continued to go down. Therefore: X does not cause Y. Q.E.D.

I love this. Astra Zeneca, Pfizer, Merck, GSK, and many, many other pharmaceutical companies are spending billions and billions of dollars on trying to control for all the factors of a single human being, and yet are unable to do so for approximately 19 of every 20 candidates that go to phase 3 trials. And here, all along, you ( though stated as "we" by which I guess you are referring to other paid members of NRA) have somehow managed to control for all factors of every human being in the United States. That is an impressive feat. Even more impressive, you have managed to reduce this incredible superhuman complexity to just two features, X and Y. Not even FOX News can boil the world down so succinctly. Well done.

It isn't an opinion. It's as scientific as it gets.

I shall leave the refutation of this part as an exercise to the reader.

Comment: Re:Extracting all the intelligence (Score 1, Insightful) 346

by fey000 (#47194563) Attached to: Did Russia Trick Snowden Into Going To Moscow?

If Snowden is a "whistleblower", why did he release so much material about things the NSA does which are not illegal? Why did he release info about capabilities which are clearly under the NSA purview and in the national interest?

Nothing the NSA did was "illegal", since they are a part of the government. This can also be seen in that no one has been arrested for what amounts to systematically breaking the constitutional rights of the american citizen.
Their actions are however highly immoral and reprehensible, which is the reason that Snowden wanted to inform the public. This because he values right over might.

Does that answer your question?

+ - Windows 8 a 'threat' to China's security

Submitted by mrspoonsi
mrspoonsi (2955715) writes "Microsoft's Windows 8 has been branded a threat to China's cybersecurity in a state-backed news report. China's CCTV broadcast a strongly critical story in which experts suggested it was being used to grab data about Chinese citizens. The report comes only days after China banned the use of Windows 8 on many government computers. Separately, other Chinese media firms called for tech firms that aided US spying to face "severe punishment". In the story Prof Yang Min of Fudan University was quoted as saying that Windows 8 posed a "big challenge" to the nation's cybersecurity efforts, "Microsoft would no longer open its Windows 8 source code to the Chinese government," he said. "However the security scheme of the Windows 8 operating system is designed to provide better access for Microsoft to users' database." The report also suggested that Windows 8 was one of the methods the NSA was using to spirit data out of the country. China has been a consistent critic of the wide-ranging surveillance programme carried out by the NSA."

+ - Censored DEFCON Presentation Posted Online->

Submitted by Nicola Hahn
Nicola Hahn (1482985) writes "Thought the Review Board at squelched Bill Blunden's presentation on Chinese cyber-espionage, and the U.S. government has considered imposing visa restrictions to keep out Chinese nationals, Bill has decided to post both the presentation's slide deck and its transcript online.

The talk focuses on Mike Rogers, in all his glory, a former FBI agent who delivers a veritable litany of hyperbolic misstatements (likely to be repeated endlessly on AM radio). Rather than allow the DEFCON Review Board to pass judgement as supposed .gov "experts", why not allow people to peruse the material and decide for themselves who is credible and who is not?"

Link to Original Source

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