I've felt it (and I've felt plenty of other buzzes, too).
Notably, I have only felt it during the (few, brief) periods in my life that I've been in excellent physical shape. If I'd start exercising but quit before tiring myself out, I'd feel frustrated. But if I exercised to a decent level of fatigue, I'd feel a strong sense of well-being.
At the moment I'm in terrible cardio shape, and all I feel when running is awful. I don't think the "runner's high" happens until you're a runner.