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Comment: Disease state (Score 1) 196

by epifreak (#34169726) Attached to: Central Dogma of Genetics May Not Be So Central
The article does suggest that the mistakes are not random. First thing that crosses my mind is can we have a mutation in RNA that will lead to a disease, although the DNA is wild type normal. I know examples where mutations in RNA lead to splicing errors producing the truncated protein, but what Li describes seems to be quite common phenomenon. Second thing is, were all these mistakes in mRNA or non-coding RNA?

Comment: Re:Not so Surprising... (Score 1) 196

by epifreak (#34169654) Attached to: Central Dogma of Genetics May Not Be So Central

Look at CJD (Creutzfeldt-Jakob Disease) or BSE (Bovine Spongiform Encephalopathy) the causative agent is a prion. A vital protein that in its normal state is essential to neurological function, which can fold in more that one way, and folded the wrong way destroys brain tissue and ultimately causes dementia and death. I'll bet dollars to donuts, that there is some funny quantum state, or a protein folding problem, or some simple nonbiological chemical process whose probable result is a code misspelling in protein formation. Its an interesting problem, but not at all surprising. We are complex systems, and trying to force the world processes that make us possible into a box is at once myopic and foolish.

Species like rabbits are resistant to prion infections and comparison of the crystal structures of prion protein in rabbits and in hamsters reveals why rabbits cannot get infected while hamsters can - its solely a protein folding problem.

Comment: Early vaccine (Score 1) 147

by epifreak (#28326485) Attached to: Swine Flu Vaccine In Production
My only concern is that the vaccine is developed against the H1N1 virus (likely neuraminidase) that is currently circulating. It does have high human-human transmission rate, but mortality is 0.5% so far, so most of the cases are mild. What is WHO scared of is this virus becoming more virulent, by say mixing with H5N1 - mortality rate 60%, thus mutating and rendering the vaccine ineffective. At least so far based on structural and bioinformatics analysis the active site of neurmainidase (this is where Tamiflu binds and prevents spread of viral particle) is unchanged, so Tamiflu will be effective for now.

Comment: Re:Everything Gives You Cancer (Score 1) 83

by epifreak (#28191115) Attached to: Scientists Can Grow Stem Cells In a Petri Dish

The hard part is differentiating them into the tissue that you want -- safely.

I bet epigenetics and cell memory will have a crucial role here. Genome wide studies showed that many PcG and TrxG genes change their expression levels during differentiation. Also, i find idea of bivalent chromatin to be very attractive - a cell has histone marks that can either silence or activate genes and depending on the context it will be tilted hopefully the "correct" way.

Comment: Re:Unfortunately... (Score 1) 193

by epifreak (#26497391) Attached to: Implant Raises Cellular Army To Attack Cancer

The tumor evolves and all that our treatments do, if they are unable to kill off the entire tumor, is select for cells that are resistant. I'm not an oncologist, although I am involved in medical research, but it seems to me that a more effective strategy would be to select for cells that are specifically weak to conventional treatment prior to administering it.

You are touching on a cancer stem cell theory. There are many labs that work on that and a number of papers demonstrated experiments supporting the theory, at least for a couple of cancer types. And as you said, the best treatment (and possibly cure) for cancer is considered to be a combination therapy: an agent that kills off cancer stem cells (does not exist yet) + chemo/radiation therapy to kill bulk of the cancer cells (variety available and work fine, albeit with considerable side effects). The problem with getting an agent to kill off those CSC is that there is limited info about the molecular and surface markers, genetic makeup, epigenetic regulation of those cells. Once we (as in researchers involved in medical oncology) have pinpointed those, hopefully an effective agent can be designed.

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