I work in semiconductor manufacturing. The very first place I worked out of college ran the manufacturing execution system on OpenVMS. It was a bit of an shock to get a log in to the VMS cluster on my first day as this was in the 2000s and I had only learned about VMS in my operating systems classes as a historical example. I have also noticed that the older Nikon imaging tools have OpenVMS running the main application controlling the tool.
I found OpenVMS to be a great zero frills system for doing this type of work. I am sure there are plenty of manufacturing sites that will be interested in the port to x86 so they can get some more modern (and reasonably priced) hardware to support their mission critical applications without having to start from scratch with a new system.