So here is my take on the matter. I fully understand that numerous websites such as Destructoid provide a lot of free (quality) content to viewers yet their servers come with increasing operation costs and therefore, ad revenue is a necessity to keep the site running without demanding a premium charge first. The same goes for several other websites. The problem is that I have encountered way too many highly abusive ads that I came to the point where I didn't WANT to shut adblock off nor do I want to go fishing through each site I visit and only enable adblock manually when they go overboard. I would rather preventative measures instead.
Point in case. I was at my brother's place and he needed help installing a Minecraft mod. I went to its download page and was bombarded with at least 5 gigantic download buttons and guess what? All of them were fake and were placed as a trap in order to get a free ad click from anyone who just wanted to download the mod. That is deceptive! Needless to say, I became very frustrated from being sent all over the place so installed Adblock on his machine soon after. After returning to the page, I eventually found the REAL download link "tucked away" BUT you had to give them a facebook like, tweet, etc just to view it. Don't believe me? See it for yourself and you'll know what I mean: http://www.minecraftmine.org/minecraft-1-0-0-modloader-1-0-0-mod/
THIS is the kind of crap that I couldn't stand prior to installing Adblock on my own machine. I've also come across ads that would slow down my machine (due to being a poorly coded flash banner), play obnoxious music, spawn a popup that abuses the unLoadEvent function thereby displaying a dialog box before it will close, or even attempt a browser hijack to change my default search provider or a drive by malware installation. Then there are the video streaming sites like Youtube which throw in half a minute commercials not just at the beginning but sometimes in the MIDDLE of a video as well which ends up being extremely loud compared to the video itself and therefore hurts my ears (I use headphones and yes I know that only partner videos have ads but hopefully you get the point I am making). I am sorry but enough is enough!
It's really nice that Destructoid heavily monitors what advertisers' banners appear but some sites just let it go way out of control and I have no way of knowing this until I hit the site. Therefore, to save myself a LOT of frustration, Adblock is going to have to stay on until the worst of ads are abolished (which does not seem very likely unfortunately). Text ads like what Google uses I could tolerate as well as small non-intrusive banners. In fact, Adblock HAS an option to allow "non-intrusive" ads and this is ON by default. Perhaps more sites should work towards only displaying those and perhaps less ads will be blocked. Only the REAL ad loathers would enable that options as well. Also, there are sites that just flat-out refuse Adblock users by inserting a script to halt all traffic that has it installed. If they really get desperate, they could do that too although I find this approach to be quite hostile.