I'd research and investigate every charity I looked to donate to, and anyone who sought me out with their hand out (besides the normal automated stuff everyone gets) would automatically get on my "no" list. I'd probably start my own foundation, really.
On a more personal level, if I hit it big, my dream is to build a sweet recording studio and finally start laying down original tracks. That would be the dream. I'm working on it now, but it's slow going. I'd be happy with that. IT pays the bills, but the stress is also taking years off my life.