And yes, I hate that Beta-thing too. (Dear Slashdot, bury it soon.)
From wikipedia's Chlorpromazine article...
The effect of this drug [Chlorpromazine] in emptying psychiatric hospitals has been compared to that of penicillin and infectious diseases. But the popularity of the drug fell from the late 1960s as newer drugs came on the scene. From chlorpromazine a number of other similar antipsychotics were developed. It also led to the discovery of antidepressants.
Chlorpromazine largely replaced electroconvulsive therapy, psychosurgery, and insulin shock therapy. By 1964, about 50 million people worldwide had taken it. In 1955 there were 558,922 resident patients in American state and county psychiatric hospitals. By 1970, the number dropped to 337,619; by 1980 to 150,000, and by 1990 between 110,000 and 120,000 patients.
Anyone with a personal stake or interest in schizophrenia, should think about those numbers very carefully. A comforting thought for anyone impacted with schizophrenia is that it is mostly of biological origin and there will be improved and better targeting medicine available. A horrible horrible thing is that I may have discovered a very good target protein for designing a medicine which would fix the schizophrenia's key illness mechanism. As a newly graduated biochemist I thought pharmaceutical companies or university PhD programs would be interested about this "discovery"; as I even had a letter of recommendation from a pharmacy professor (a specialist in psychiatric medicine) certifying that I have apparently discovered a new & interesting model of schizophrenia. When applying for all relevant job positions all over the world, I soon found out exactly no one was interested. Apparently the HR departments were unprepared for this kind of "innovative" applicants.
It isn't very funny, considering I spend a year! at a university library building a disease model; read ~10,000 Medline abstracts, 100+ full articles, 10+ full books. All that just for the purpose of following all the known clues that might lead to the schizophrenia's root cause. Oh and I started that massive modeling because I knew I was very good in building abstract models; for example patent office had been kind to give me patents. And the situation isn't particularly funny for the schizophrenics and their family members eater. ~10% of schizophrenics will end up killing themselves during their lifetime. Considering the average lifetime prevalence of schizophrenia worldwide being ~0.7%, you could estimate there being 7 billion * 0.007 = 49 million schizophrenics out there and about 5 million of them will commit suicide. If we further assume a post diagnostic average lifespan being 35 years, that gives us a an estimate of 142,000 schizophrenic suicides per year - roughly 400 suicides per day. And I've been sitting for years on information that might significantly change those numbers.
So dear schizophrenics (and your beloved relatives), Yes it really is ironic that the information you need the most in this world may already have been found (who knows maybe even by other researchers) but that critical information may just have be neglected. And don't blame me for that!. I really begged a relevant job or any kind of grant money from all possibly instances - even instances which are supposed to exist just for financing making this kinds of "discoveries" starting from NARSAD and ending to the Scottish Rite of Freemasonry.
The only one who has seen that novel schizophrenia model is that pharmacy professor - who warned me he would give the 20 page handout tough review. Couple of weeks later I called him and asked "am I barking a right tree? In short, his answer was: "YES".
That said, schizophrenics should not kill themselves, nor quit the medicines. One day there will be a new kind of specifically targeting antipsychotic medicine; without the side effects of these current (quite unspecifically) binding antipsychotics. Oh yes, and someone really claims to want to find the cause and cure for the schizophrenia they can feel free to finance a PhD study position for me - in which no actual medical experiments are needed. The model is new, good, and enough ready to be written on paper. If you are a Bill Gates and want it, finance it.
> Just to remind you Mr. Anonymous Coward a hundred of million persons were killed by their own governments during the last century. What makes you think govermnents 20 years from now will not execute jews, communists, homosexuals, retards or gypsies like they did in Germany(in 1930-40's), or they will not execute people living in cities or wearing glasses, Buddhist monks, Muslims, Christians, Western-educated intellectuals or educated people in general or people who had had contact with Western countries or with Vietnam, or with any previous government, or disabled people, or the ethnic Chinese, Laotians or Vietnamese like they did in Cambodia (in 1970's), or they will not execute capitalists like they did in Soviet Union(in 1920's), or will not execute muslims like they did in Bosnia-Herzegovina (in 1990's), or will not execute Tutsies like they did in Rwanda(in 1990's), or they will not execute the well educated class like they did in China (in 1960's), or they will not randomly kill people of other religious groups like they did in Iraq (in 2000's) or they will not bomb to pieces urban areas which do appear to be supportive to a currently reigning dictator like is happening in Syria (in 2013).
Now pick your country for the next decade, Are you feeling lucky, punk? or maybe you still like the current development e.g. the great firewall of China and some high profile websites starting to use HTTPS.
I think TOR-like backbone to the future Internet is a great idea. Some tweaking, sweat, toil and tears and it will be a great system.
Finland's eco-mobilist association has a gallery of hobbyist build wood gas mobiles, some even with designs specs and tips. Chairman on the Finland's currently most popular party, which unfortunately isn't The Pirate Party which among others has pirate bay and privacy activist Peter Sunde as a candidate in the coming EU- parliament election, has build his own wood gas automobile - " El Kamina" which by the way is build on top Chevrolet El Camino, which...
No, I didn't just wrote that
Most of those ex-Nokia, ex-Renesas people are located in city of Oulu in Finland, and a few months ago all of them almost went unemployed because Renesas run out of money; right when this new modem tool was ready for the markets. And miraculously their jobs were saved by the bell... by the Broadcom's offer.
Broadcom now laying off its people is just an aftershock to Nokia's and Renesas' failures to utilize their former talent pools properly. These kind's of event, once again, hi-light the fact that Nokia was once doing all kinds of right gizmos. But unfortunately its leadership has been failing the company for a full decade now. In fact, those who have been leading Nokia during the last decade should never hired for any non-gargoyle jobs. The kind of waste of human creativity and stockholders' property they caused is just sad.
A DNA a programming toolkit, known virus sequence and a PCR device... easy to predict that this will result lots of bad news.
Maybe UN should publish a short up-to-date list of potentially dangerous scientific pathways never to be taken, articles never to be published and things never to be done or sold. Research that might lead to an easy to use DNA programming toolkits should be right on top of that list.
Besides mad cow disease is already ancient history. What could possibly go wrong?
Uh... were you ACTUALLY asking what could possibly go wrong? Because that's usually sarcastic.
Yes, That was the sarcastic part.
Anyway, I don't understand what mad cow has to do with anything either way.
well try this,
Yes, the sarcastic part was hidden under the layer of science... but this is slashdot and it's ok to do that here.
The potential as doping
I don't see this as a breakthrough. Breakthroughs are for sciences with hard walls to break.
I consider this technology opening a door to a paradigm shift in many fields. As you point out, living organisms have few / if any hard limits. However, consider that a human genome has only about 20,000 protein coding genes, so there is a certain (diffuse) limit, what those genes can naturally catalyze or achieve. Yes, there are lots of special action proteins like luciferase that are beneficial to certain specific organisms. But there are also remains a wide range of reactions which don't have a good enough or utilizable / suitable natural biological 'producer'.
For example almost all biological organisms do bad job in breaking poisons like dioxin. As this new technology advances it might be used for catalysing all kinds of specific reactions for which there's no actual need in 'traditional' living organisms.
Yes this may be the end of meaningful doping testing, but also the end of cancers and many auto-immune diseases.
Besides mad cow disease is already ancient history. What could possibly go wrong?
Reporters without borders sure sounds like a global network of these terrorist-journalists - "douple tap" that too!
This is a chicken game. If many key wikileaks people would suddenly disappear, then Snowden (or other heroes) would probably release both encrypted insurance files and the encryption key to the smaller (49GB) insurance file. At least I hope that's what they are prepared to do. Then the NSA and GCHQ would probably have stopped the attack, at least for a moment, and considered the nature of payload data in the first insurance file. Based on that payload NSA might then choose to risk the release of the 349 GB file or they might stop their attack... maybe even for good. To prepare for the next attack phase Snowden (and other heroes) might again have split the remaining 349GB file into a 300GB and 49GB file - the small file being there again as a similar first response tool, but also the key to the nuclear option file (349GB) might also be released at any time.
Basically the NSA and GCHQ had to get this message.
This is so stupid, Snowden is obviously an American Patriot, who still isn't really seeking to harm his country... a country that is trying to harm him as much as it can. It is not very common that asylum seekers keep protecting the country that is doing all it can to harm the asylum seeker. Thus, the today's release of encrypted insurance files was probably just an expected reply to the earlier provocation by the NSA and GCHQ.