If you can't have a consistent experience across even one day, why get too reliant on customizations and shortcuts?
Back in the day, I had to switch between Data General (terminals), MacOS, and Amiga keyboards and UIs on a daily basis between work and home. These days, of course, everything has changed - now I bounce from Linux to Android to OSX, and more than occasionally Windows too. It's just never paid off to build a super-custom setup when you can't stick with it.
I use Linux for my main desktop at home partly because it is so quick and easy to reinstall - just keep your data on a backed-up server and you can virtually forget about maintenance or troubleshooting. Get used to the default setup and just reinstall whenever you run into something you can't work around - 15 minutes to get back to a familiar desktop is quicker than any full restore-from-backup I'm aware of. (I actually like Linux internals but every time I learn something, I end up forgetting it before I need it a second time; it gets frustrating...)
I'm aware I'm giving up a fair amount of potential productivity and convenience. I don't care any more. I'm just happy when I remember not to try and touch the monitor on my wife's iMac.
I got friends and colleagues who, for example, use Dvorak. More power to 'em. They're younger and more stubborn than I, and most of the time they have one laptop they use both at home and at work. As a wise man once remarked, I'm older now, I got to move my car on street-sweeping day, I can't be doing just anything I want any more...