bmahersciwriter writes: Citation is the common way that scientists nod to the important and foundational work that preceded their own and the number of times a particular paper is cited is often used as a rough measure of its impact. So what are the most highly cited papers in the past century plus of scientific research? Is it the determination of DNA's structure? The identification of rapid expansion in the Universe? No. The top 100 most cited papers are actually a motley crew of methods, data resources and software tools that usability, practicality and a little bit of luck have propelled to the top of an enormous corpus of scientific literature.