I re-image mine from an image I made, stored on a server in the middle of the house. Every time the machine boots, it re-images the OS image on the local hard drive, thoroughly destroying anything else that might have been on the disk. When an update to the main image is necessary, I make a new one.
I create those once about every six months, unless there's an emergency patch like Heartbleed. This works on all of the computers in my home. Wife and daughter go through the same process on their machines.
Boot to Ghost, install os, play, run, do whatever. In the event of a virus, it's short lived. When I attended Berkeley, this was the way they had set up their computer lab. I remember, at the time, being intrigued by the setup.
Now that I have myself, my wife, and a five year old all using machines around the house (nine distinct pc's), I have a practical use application for this.
Since I implemented this about five years ago, we have had virtually no problems with it. The drawback of course is that it's a lot easier to do if your machines, desktops, laptops, etc, all match. Learned that one the hard way, but good now.
My machine gets shut down about once a week. My daughter is always letting the battery burn down on her laptop, so she images more frequently than anyone else in the house. My wife is also at about once a week.