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Comment Re:Side Effects (Score 3, Informative) 41

I have a friend with Friedrich's Ataxia, and CRISPR is one of the silver bullets she's praying for. FA cripples then kills you: wheel chair by 25, dead by 40 is often the case (it hardens the heart so it can't pump). While CRISPR has some unknowns and risks, having FA is a certainty. FA affects a single gene pair, so if you can replace either side of that gene, you have solved the problem, the mitochondria will start producing frataxin again, and the nerves will stop being slowly destroyed.

There are no treatments and since it is so rare (1 in 50,000 have it in the US, 1 in 30k in Europe, almost no one in Africa or Asia), few are investing in finding a cure or treatment. FA isn't the only orphan disorder like this. So yes, I'm quite happy to see CRISPR move forward.

Comment Re:No (Score 2) 269

You forgot margin. They have incredible margin on their products. Their concern is total profit, not units sold. They could easily drop their prices in other markets to keep market share, but the net profit to them might be lower. It isn't like iPhones prices are anything relative to their cost. Their price is based on what people will pay.

Comment Re:Fools think this is horrible. (Score 3, Interesting) 442

Im not sure this is a helpful distinction. Fascism was a much more complicated beast than simply the collusion of government and capitalism. There was an underlying mythology of the nation and of violence. Fascism was the glorification of the dictatorship of the nationalists, and all had to fall into compliance, citizens, companies, the military and so on, and any opponent was to be smashes with maximum violence. I dont know this exactly describes this. Certainly the tendency towards unreasonable patriotism certainly doesnt help, but its not quite fascism, its something else....

Comment Re:Paper doesn't account for successful theories (Score 4, Insightful) 303

It *does* account for those. The probability is based on how many people would have to be in on it. The moonlanding hoax and the "climate change is a hoax" conspiracy theories require incredibly large numbers of people to be involved and thus would have been quickly discovered, but since theres no evidence either of them are a hoax and the time scale involved, we can thus conclude theres no conspiracy. The nixon vietnam talks conspiracy however involved a small number of conspirators, and this greatly increases the likelihood of a conspiracy succeeding.

Comment Re:answer: no (Score 2) 190

Does he mean that blockchain that is already having trouble scaling in a Bitcoin market of meth dealers and Russian ransomware jockeys? What would happen if we tried using it to, say, keep track of the world's Visa transactions?

Internet humor is defined as tragedy that ends with the words "and then I lost my bitcoins".

Pray that doesn't become "and then I lost my visa".

Comment Re:First amendment (Score 5, Informative) 117

The first amendment right is a right to speak. Its not a right to force others to listen.

No first amendment rights are being violated here. There is a do not call list that people opt into that means "This person does not wish to recieve your phone calls". If you think that allowing people to be forced into hearing others speech is OK, then fine, but lets not pretend that position is about defending rights.

Comment Forth (Score 1) 414

Well not really a toy language (It has some very serious uses as a "toaster code" language), but its great fun to screw around with. Its basically an inverted lisp that works with stacks instead of lists, and it can be surprisingly powerful in the right hands due to its ability to cook up complicated datastructures and things to do with those structures. In its basic form , it doesnt even have a concept of a variable ,well not one as commonly understood in other languages. A page or two of code later, and its object oriented , running coroutines and all sorts of esoteria normally only found in the "big boy" languages.

Comment Re:Something Awful should file an objection to it (Score 1) 111

So then it's something completely different? The current trend of 'lets play' has, afaik, nothing to do with watching each other and everything to do with being watched.

In some ways yes. However term itself did come from SomethingAwful. The actual youtube video format that emerged since can be attributed to a dude called "slowbeef" who, not surprisingly, was a somethingawful member.

Comment Re: too much $, but no, 3 months pay (Score 1) 186

Bill the city/state? Are you an idiot? The police department doesn't just "fix crime" and send a bill to the tax payers. They ask for more and more funds all the time, so that would get lost.

Whether or no 36k is reasonable or not, the courts can decide. It sounds a little high, but not extraordinarily high.

Comment Re:Penny (Score 2) 702

We did the same here in Australia, maybe in the 80s or early 90s. Removed the 1 and 2 cent copper coins. Around the same time we moved 1 and 2 dollar notes to coins. Didn't have a lot of effect, other than making the minimum bag of lollies 5c instead of 2c (Hey, I was a kid at the time!).

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