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Biotech

+ - Protien in HIV functions as resistor

Submitted by
TwilightXaos
TwilightXaos writes "Leor Weinberger and Thomas Shenk, two researchers at Princeton, have discovered a new model for how the HIV (Human Immunodeficiency Virus) enters and exits dormancy. They claim it functions as a resistor, this is in contrast to other types of regulation models found in other viruses and animals. From the abstract:

Here we show that a dissipative feedback resistor, composed of enzymatic interconversion of the transactivator, converts transactivation circuits into excitable systems that generate transient pulses of expression, which decay to zero. We use HIV-1 as a model system and analyze single-cell expression kinetics to explore whether the HIV-1 transactivator of transcription (Tat) uses a resistor to shut off transactivation. The Tat feedback circuit was found to lack bi-stability and Tat self-cooperativity but exhibited a pulse of activity upon transactivation, all in agreement with the feedback resistor model.

The research could lead to an effective treatment of the HIV virus, and has the possibility of increasing understanding of other viruses like herpes.
Additionally hindu.com has a article on the findings."
Music

+ - Is AllOfMP3.com All washed up?

Submitted by
TwilightXaos
TwilightXaos writes "US Trade Representative Susan Schwab has been quite clear and open in the past few weeks that he, and implicitly the US Trade department, would like the site AllOfMP3.com shut down. He is quoted by ArsTechnica as saying
at the top of the 'notorious markets' list is Russia's allofmp3.com, the Web's number one pay-per-download music site whose catalog consists of illegal copies of music from U.S. recording artists and other right holders.
Ars Technica also recently(last month) reported that the site, allofmp3.com, was in danger of being shut down due to changes in russian IP law. Though that article concludes that other pending changes in Russian law, and the possible withdrawal of Russia from WTO talks for unrelated reasons could migigate the danger to the music site."

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