I like the parent posters have both the native and (several) wine installations.
As games get ported I remove them from the wine installs and add them to the native client.
At the moment I'm actively playing (thanks to the recent sales)
Native: TF2, World of Goo, SS3:BFE
Emulated: Skyrim , Deux Ex:HE, CS:GO, XCOM
When the rest of the Source games get released I'm sure I'll be playing through HL2 again and possibly killing some more zombies with friends ( LFD 1+2 )
Also I'm running on Gentoo and the native client wasn't difficult to install though I'll certainly appreciate it once there are a selection of distro specific packages or some logic to simplify installs inside the main steam installer.
Other family members have Mint installed and steam was trivial to install there.