I concur. I've used a Kinesis Ergo keyboard for many years. With a normal keyboard I used to find that I'd get pains in my little finger, especially on the right hand. Shortly after starting to use the Kinesis, those pains vanished.
The main keys that are normally pressed by the little finger (control, alt, backspace, enter, home, end, windows) are switched to the middle of the keyboard and used by the thumbs. Takes a little getting used to, but before long you'll be using those keys without thinking.
Shift is still in the usual spot for the little finger, however mine also came with a foot pedal that could be used for shift (or anything else, as it was also programmable). (I never used the foot pedal)
The only caveat is that they are expensive.