When you don't have friends, cards are really just a stack of colored paper. That's the problem I've always had with Dungeons and Dragons and multi-player games like that. When I was a kid I used to buy D&D books and modules and be fascinated with the lore and how much fun it all sounded. But when the realization hits you that you don't have anyone to play it with, it all becomes pretty useless.
I ran into a similar issue. (1) Very small circle of friends. (2) None of them interested in playing role playing games like D&D. (3) People get married, buy houses, start pumping out kids, and aligning schedules becomes near impossible.
You're not alone in being alone. I recommend something like an MMORPG where you can meet people and develop online friendships. My favorite has always been EverQuest.