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How do I do that you ask? Oh - a nice little program I bought several years ago called GameJackal. It builds up a "cache" of the cd the first time you run the game, then you just pop out the cd and play happily without it in future.
It's not perfect, but as it does almost every game over 6 months old without any problems, and only a few problems with newer ones (till it's updated etc) I'm quite happy... Even means I can run game updates without having to uninstall nocd patches and find new ones...
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