The human mind does have limits, driven by the assumptions we learn or develop as we age, and also by our senses. We can only directly perceive a certain number of things that we can see or touch or feel or taste.
The universe may be full of dimensions and forces and things we can't see and therefore don't know about. Dark matter is one, something we know little about and can barely detect yet it is apparently the most common kind of matter. And we can't even see it, touch it, anything.
If there are other things like dark matter, well, we can't see them and don't know about them and have no theories about them. Our view of the universe will never be complete and we wouldn't even know it. Some people say they see ghosts or sense things. We dismiss them as delusions or worse and never take it seriously as an aspect of something we cannot normally detect. We write it off.
And then we have this very narrow assumption about where life can exist; the so-called Goldilocks zone. We refuse to believe there is any other possibility. Yet we admit we don't know everything about the universe. We are shocked when we find worlds with the same geologic features we have here. Why are we so shocked that things are the same?
But if we don't know even know sand dunes form the same in many places (holy shit, it should be news if they DIDN'T, not that they DO), how do we dare make this judgement about where life can be? Why do we assume it has to be life as we know it? This view is ridiculously close to the idea that the Earth is the center of all and the template for all. And it's wrong.
The only thing we know for sure is that we don't know an awful lot. And yes it may be beyond human comprehension to ever really know what's going on.
It does not help that we spend a huge chunk of our lives learning basic schooling, toil for a while and then die. We don't live long enough to actually spend a long time examining the universe. We lack perspective. We spend too many good energetic years stuck in classrooms learning the way people learned 200 years ago. Hell, we still embrace Greek concepts of higher education that go back thousands of years. Is this the best way? Nobody knows because nobody will try anything else.