My experience (which may have worked only for me mind you) is that employers don't give a toss about how much you know about stuff, but how flexible, adaptable and quick to learn you are.
In the 20-so years I've worked, I've held 4 positions in fields that have absolutely nothing in common. I worked as an employee, I worked self-employed, and I have my small business on the side.
Whenever I meet a potential employer, I am proud to say that I can learn anything quickly and become proficient on my own, and now I have a fat enough resume to prove it. Yes, I have an engineering degree, but the only thing it proves is that I'm patient and dog-headed enough to sit through years of boring classes, and that I'm clever enough to understand how teachers want the exam questions answered (which is not necessarily the correct answer). The rest of what I did in my life was self-taught, and employers seem to appreciate that much more than what I learned at school.