I don't run an ad-blocker, but my company's WebSense configuration is blocking a good 95% of them for me. I'm starting to run into problems where websites are assuming that I'm running a blocker and are refusing to serve content*.
The bigger problem is that what if an ad network is unable to serve an advert? Ad-block detectors generally work by checking if they got a result back from the ad server. If they don't then they assume the client is at fault and either block the content or redirect to another page. Are we soon going to start seeing websites randomly redirecting because there was a network error?
* Granted, I should be working, but I'm entitled to a bit of downtime every now and then, aren't I?