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Comment: Re:The Fix: Buy good Chocolate! (Score 2) 322

by RDW (#48397925) Attached to: MARS, Inc: We Are Running Out of Chocolate

How much do you think a standard Hershey Bar (plain, 43g) should cost in $USD? Genuinely curious.

I'm no chocolate snob, but you couldn't pay me to eat that stuff. Who ever thought it would be a good idea to add sour milk to perfectly adequate chocolate? It tastes like they've mixed it with baby vomit. As an emergency measure, all cocoa intended for Hershey's production should be seized and used to establish a National Cocoa Reserve. Only manufacturers with a track record of selling an edible product (like Ghirardelli) would then be allowed to draw on it. Sound reasonable?

Comment: Re:yet another duplication of what's out there (Score 1) 105

by RDW (#48376799) Attached to: How YouTube Music Key Will Redefine What We Consider Music

Here's what the pie is. The pie is a market. The pie is cuttable into unlimited slices. Who gets the pie, depends on if they get into the market. Getting into the market guarantees them a slice of the pie. This is why Google entered the market. Because of capitalism, gobbling up as much pie as possible is always desired, even if it's unnecessary and duplicates what's already out there a million times over.

I don't understand! Do you have a car analogy?

Also, does this mean no more free pie? Will google crack down on Youtube downloaders and ad blockers that already give naughty, naughty people most of the advantages of this service for free..?

Comment: Re:Real article is here (Score 4, Interesting) 275

Rather an odd study. Viral DNA apparently present in nearly half the subjects. They went straight to a mouse model before attempting to confirm the (small) effect in a larger, independent human cohort. No evidence that the virus actually infects mammalian cells, which would be an extremely unusual host range (the only precedent of anything similar they could find to cite is in an obscure Ukrainian journal). I'd say 'more research is needed', but maybe that's just the virus talking.

Comment: Re:This is safe? (Score 1) 198

by RDW (#48324357) Attached to: Ebola Nose Spray Vaccine Protects Monkeys

And on that point, has anybody actually isolated and sequenced a confirmed ebola sample from a human subject who died from that specific infection in the affected region?

Yes, there are complete genomes from 78 cases (not necessarily fatal, but with confirmed EVD) in this publication alone:

http://www.ncbi.nlm.nih.gov/pu...

This genomic sequence cannot be detected in uninfected individuals. It simply isn't there. Run the analysis on a thousand random blood samples from, say, the US or Europe, and you'll never see it. Does that suggest anything to you? (I assume from your language, which is similar to that used by HIV denialists, that it might not!).

Comment: Re:ebola doesn't have DNA - it has RNA (Score 4, Informative) 198

by RDW (#48321847) Attached to: Ebola Nose Spray Vaccine Protects Monkeys

The vaccine vector is an Adenovirus, a DNA virus. The recombinant Ebola virus gene it carries will be in the form of DNA, designed to encode the same protein as the original RNA gene in the Ebola virus. It's the protein that is important, since this what the immune system will raise its response against.

Comment: Re:This is safe? (Score 1) 198

by RDW (#48321729) Attached to: Ebola Nose Spray Vaccine Protects Monkeys

Viruses are really damned small, and finding the right organism in an infected cell is anything but easy. Cells are full of all kinds of molecule-sized bits and pieces of shit. As of today, it is not even a certainty that the ebola virus has been positively identified, let alone properly categorized; there have been reports of over 250 mutation variants, any of which might be a mutated ebola virus, or maybe just another virus which might just have been present through the isolation process. Maybe just random bits of crap from a previous disease vector or vaccination injection. Nobody really knows for sure. It's pretty murky down there, and determining which organism causes what effects is a sloppy science, and it takes a huge amount of time and energy to even approximate answers.

Viruses are indeed really damned small, but not much else is true in this paragraph, which is mostly FUD. Nobody outside the ranks of medical conspiracy theorists doubts that the Ebola virus has been positively identified. We are about as certain of this are we are about the identity of, say, a tiger or an oak tree. Its genome has been completely sequenced many times. Yes, mutations have been found in viruses from the current epidemic that weren't found in previous outbreaks. There's nothing surprising about this - we see it every time the virus emerges from the animal reservoir and causes a new outbreak. There is no question of this being just some 'random crap' or anything to do with vaccinations. The mutations occur at specific positions within the well-defined sequence of the viral genome, and if you are so inclined you can go along to the UCSC genome website and see exactly where they are: http://genome.ucsc.edu/cgi-bin...

The specific viral genes selected for insertion into the (adenovirus) vaccine vector weren't chosen at random - the Ebola virus has been studied for decades and there is a great deal of data on the functions of the proteins that its genes encode. Of course we can't know for sure if a new type of vaccine is safe and effective until it is actually tested, but this is a long way from just having some sort of vague hunch that it might be OK, as you seem to be suggesting.

Comment: Re:Classic shell (Score 1) 242

by RDW (#48252861) Attached to: OEM Windows 7 License Sales End This Friday

If you like living on the edge where any windows update can obliterate your copy of Windows and make the UI unusable.

Sounds like FUD. Classic Shell, occasionally updated, has been perfectly stable for me over the last 18 months or so of Windows updates. Install and configure Classic Start Menu (switching off all the charms and hot corner nonsense) and spend a few minutes setting file associations to not load any Metro apps, and you've got a perfectly decent version of Windows with some improvements over 7, like faster booting. The window decorations are a bit flat, but I never liked Aero Glass either. Windows 8 ought only to be a problem for inexperienced users who don't yet know how to deal with its annoyances, people stuck with locked down systems, and MS shareholders. Surely most people reading Slashdor don't fall into these categories?

Comment: Re:There is a better drug in my opinion. (Score 1) 102

by RDW (#48185713) Attached to: Canada Will Ship 800 Doses of Experimental Ebola Drug to WHO

Although I did not mention it in my original post, I am extremely skeptical of the evidence for polio vaccines' effectiveness.

Then I'm afraid it's pretty unlikely we can have a useful discussion. There is still no fully effective cure for entrenched belief in anti-vaccine conspiracy theories (or HIV 'scepticism', if you also subscribe to that).

Pound for pound, the amoeba is the most vicious animal on earth.

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