The number one problem is at the input interface: People will only use it if it's useful or there is someone standing over them with a cosh. So how do you do that? By finding applications they find useful for their knowledge or sharing knowledge. Progress report, interface specs, requests for changes or whatever the knowledge generators want. So it's a management problem.
Say to management, "I have this as a solution, I think it's the most flexible, can we give it a try? Look! I've piloted it on my latest project and see what it can do... Think how useful if..." When management champions it there is some chance of it working. Until then paddle your own canoe and offer to show people how clever you are.
It's a good overall question, but exactly the same issues apply to 'Enterprise'(whatever that is) and novelists trying to keep track of places, people, timelines, todos, feedback etc. Until you've really put any solution (I've tried all sorts over 35 years and keep coming back to a book of notes or a master notes document.) to the test by actual use you won't understand the practicalities. The human brain is a pretty good filter if you can do basic organisation and remember to make notes/put things in the right place.