They should have a view different to the usual Star Fleet. Perhaps a small bunch of misfits trying to avoid the Federation, just making a living doing whatever needs to be done, keeping a low profile.
But one of their members is more than they appear, and the Federation REALLY wants their living weapon back.
I know, I know, it'd be easy to create Firefly lite in the Star Trek universe, we had a bit of a bash tabletoping such a thing a solid 10+ years before firefly, but we had Ferengi/Romulans and a tank/Klingon. The cloaking device always needed topping up, but it was a fun campaign. When Firefly came out, we were sure the writers had been sat in some of our sessions, even some of the dialogue sounded familiar ("I'll be in my pillow fort")
But... I'm just bored of the sparkly feds, the honourable klingons, the sneaky ferengi blah blah blah, I want to see a different view of what we're used to. Firefly could almost have worked in the ST universe. Almost. Hopefully we get that, and not the filler episodes we had so much of in the past.