Think about what the US was like even 50 years ago. Xians ran our culture through and through. You couldn't be black, gay, weird, commie, or even dress bad because Jebus. Things are changing so fast. All it will take for the stupid religious BS to die is something quite possible: alien contact, cheap power leading to the end of scarcity, even microbial life on another planet that clearly evolved separately from our planet, who knows what it will be that will make all that stuff seem irrelevant.
Humans have a need to believe in something big, and religion has typically filled that irrational need, but there is no reason it has to be religion. It's just been handy. I see a lot of changes so far, and plenty more potential changes.