Chances are this is too late to be read, but here's a reply to "what's the worst". A particularly cruel punishment, I think, is suffered by the would-be customers or partial customers who are unable to raise enough money "in time". This list includes cases of people left devastated, sure that if they'd only been able to raise more money, or raise it faster, their loved one would have been able to be saved. If the patient started treatment, chances are that their family is broke, have lost someone dearly loved, and are forever haunted by "if only I'd been able to raise money faster it wouldn't have been too late."

People who sell "hopes" at high prices steal money from believers who can meet their price, and peace of mind from believers who can't.

Always been viable? The first ship to successfully travel it from west to east took three years (1940-1942). And that wasn't even trying it out as a trade route.

At least in South Africa at this time of year they may notice the results of global warming themselves. I remember hearing of one climate meeting a few years back that was held in Ottawa in winter; the weather didn't exactly provide an impression of global warming, and may have left attendees thinking that warming might be a good thing.

Some politicians are sufficiently toxic that I doubt the bugs would go after them.

Not sure the Canadian North can count as "more usable land" once thawed -- it's largely frozen muskeg swamp at the moment, somewhat usable due to permafrost since at least that way you don't sink into it.
There's some interest in the northern seabed for gas exploration.

We don't instantly dismiss, at least I certainly don't. I look for the published records of properly carried out trials, don't find any reputable ones, and then I dismiss.

In this case Burzynski apparently doesn't even have a proper trial protocol, and no credible statistics could result. He's also been at it for quite a long time (30+ years!), much longer than it should take to do some proper testing. Hence.... quack.

Look, you don't get to reverse the burden of proof on treatments, where we should accept any claims unless they've been disproven. There are far too many wacky claims to be able to use that approach, even if it was appropriate. If the proponents of any treatment want it to be labeled as genuine rather than quackery, then carry out proper trials and produce reputable publications. Choosing not to do so suggests that the proponents themselves know that it's quackery.

If someone wants to do testing on the effects of chewing a measured amount of certain roots -- go ahead. I suggest you not smear your submitted papers in goat blood, though, and be careful about dosages if you haven't isolated the compound.

you wanted an argument? sorry, this is abuse. (oblig. Python)

Though maybe he's lying about not thinking lying is wrong.

An advantage to blogging about the new victims is that it can provide some sort of external record of at least some of the patients. Since we know about them before they sought treatment, they aren't cherry-picked "success stories" like the other anecdotes.

Meanwhile, the UK government is currently looking into reforms to their rather chilling libel laws (burden of proof is reversed from the US laws, with the defendant having to prove the truth of their statements), so this set of threats and the attention it's getting is potentially helpful.

The commenter probably has a karma bonus, which means that at some other time this person has said something intelligent.

"big pharma" isn't a monolith, it includes multiple competing companies. Any of whom would be happy to buy up a likely cure and make large amounts of money from it. Over the patent life of a drug, you shoud be able to make much more money from a cure than an ongoing treatment, because you can charge a lot more for it and you get all of it upfront.

And then, once they're cured of the fatal disease, you can still sell them all of your other drugs!