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A windows file system that deals with bitrot, provides quick system restores, and bulletproof data recovery is long overdue. If ZFS and Btrfs can exist in the Linux world with a small budget, I'm sure the largest software company in the world can pull off a nextgen file system too. Protecting data on PCs is still ad-hoc, Most consumer users can't be bothered to automate their backups even with existing utilities in Windows. They do silly things like back up manually to USB keys... occasionally. The vast majority don't have secondary drives.
PCs should just do data protection right out of the box without user input. Ideally the OS should even encourage the existence of secondary drive with a notification upon first use. (scold the manufacturer as inferior product for not putting it in with a warning... your data isn't safe) Sell Windows with cloud backups as a built-in feature (with opt in question during initial use). Hook customers in with free backups for first year.
Add more robust virus and spyware protection. Create a far better firewall (something like peerblock's list system baked into the system). Make it easier to clean out the system of unwanted apps... without having to reinstall everything again. Windows store is a step in the right direction but it shouldn't mimic Apple's and Android's Orwellian control freak model (that also sucks up the profits of app developers) Reverse the model. Apps that are installed in windows instantly also become store apps aligned to their personal account. This way anyone can install anything on their system and immediately have a full system recovery even if the hardware dies. Get the job done.
With the rise of mobile, at this juncture Microsoft is no longer in a monopoly position. The DOJ should allow it to add security and data stability features to the desktop without having a cow. If competing companies don't like it, tough. Free enterprise. Either do it better or get out of the way of those that can.
There is of course another, rather unholy, possibility for the cross-species jump.
This might be useful for transporting animal life but not humans. A astronaut coming out of a long term induced coma would have severe muscle atrophy. There is also extreme risk that an astronaut would stay in coma (with no medical facilities to deal with any complications) Makes for good science fiction but highly impractical any time soon.
A better approach to long space trips... one way travel. It greatly lightens the mass of the spacecraft. In addition, break up the mission. First send automated ships with supplies, habitat and tools. Then send colonists not tourists. If Mars colonies get big enough, they will eventually have the capacity to be build launch facilities of their own. These could be used both for a return to earth and missions deeper into the solar system.
The first few colonists to Mars will be responsible for setting up self-sustainable facilities that can be expanded using local resources. After that's done the chief Mars colonist requirement will be to be youth and fertility. The cheapest way, by far, to get humans on Mars: make them there.