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Comment: Not completely new: (Score 5, Interesting) 49

by Hartree (#49500805) Attached to: Resistance To Antibiotics Found In Isolated Amazonian Tribe

This is more confirmation, but it has already been known in the microbiology community for some time.

Many of the genes that contribute to antibiotic resistance are far older than human use of antibiotics.

How can that be? A couple ways. Mom Nature has been playing the antibiotic game for a very long time. Most of our antibiotics come from antibiotic producing organisms in nature (penicillin for example). The countermeasures have long been out there, but only in a small percentage of the bacteria out there, since there is a small cost to maintaining any given gene. When there is a big exposure to a particular antibiotic, the resistance genes spread through the bacterial community and become common, as we often see nowadays.

The other source is that an enzyme that is used for some other purpose may well have some ability to protect against an antibiotic. An example would be a transporter molecule for some substance other than the antibiotic to be pumped out of the cell that is close enough to sometimes pump out the antibiotic. There would then be strong pressure for the bacteria to make more of that transporter protein when the antibiotic is around. Nature is good at using something it already has for a new purpose.

That's one of the reasons antibiotic resistance is such a problem. Mother Nature has been playing this game a very long time and frankly is better at it than we are.


A 2-Year-Old Has Become the Youngest Person Ever To Be Cryonically Frozen 310

Posted by Soulskill
from the rest-in-peace dept.
merbs writes: After losing a long battle with brain cancer, 2-year-old Matheryn Naovaratpong became the first minor ever to be cryogenically frozen. This article is the story of how a Thai girl was frozen in Bangkok and shipped to Arizona to have her brain preserved in liquid nitrogen, while medical science works on a cure. "Typically we’d move the head from the trunk of the body. We didn't know what their reaction would be from the family, the mortuary, from border officials; this has to go through a number of shipping venues, customs, the TSA and so on. To see a frozen head in a box might have raised a number of red flags. In the U.S. that’s not a big deal, but there, they may not be accustomed."

+ - Dark Matter May Not Be Completely Dark

Submitted by StartsWithABang
StartsWithABang (3485481) writes "If you take two clusters, groups, or individual galaxies and collide them together, you'd expect the stars to pass through unperturbed, the gas to experience friction, slowing down and heating up, while the dark matter, if it's truly collisionless, will do the same thing as the stars. But if there's a tiny frictional force at work on dark matter, it, too, will slow down a little bit. A team looking at 72 groups and clusters saw no effect of slowing down, but then on the 73rd one, they saw a separation between the mass reconstruction and the stars. Is this the first sign of dark matter's interactions, or is it simply an astrophysical effect, or maybe even a fluke? A good recap and rundown of what we're looking at to the best of our knowledge."

Comment: Re:Zoloft is a 1000 times worse (Score 2) 186

by Hartree (#49467793) Attached to: Acetaminophen Reduces Both Pain and Pleasure, Study Finds

One of the problems is that depression isn't a single process. It's a symptom, and we lump a lot of things under that name.

The exact details vary from patient to patient. Also, the differences in the way the drugs used to treat it are metabolized in different people can be pretty significant.

I've taken Prozac for nearly as long as it's been available. It works well for me. When I've gone off of it to see if I could do without, the depression came back on a pretty predictable timeline. I tried another antidepressant, Effexor, and that didn't work so well for me. The additional effect it has on norepinephrine as well as the serotonin system (I'm guessing that's what it was based on what we know about how it works. YMMV) made me a bit too up, i.e. slightly hypomanic.

The SSRIs don't work for everyone. It's usually taken about 3 tries for most of those I know who are taking them for definitely diagnosed depression to find the right one/the right dose. For a goodly number, they just don't work that well.

The certainly aren't the only class of drugs that are like that. Blood pressure medications often have to be tailored in dose and kind before they lower the pressure enough without too many side effects.

As another anon (maybe you) mentioned, regular exercise works very well for many people. But again, not so well for all, either due to inability to exercise, or just not working as well as in other people. (In fact, regular exercise programs are an excellent thing to try first in depression, IMHO as soon as other common medical causes like hypothyroidism are ruled out).

As others have mentioned, when you're first starting a new antidepressant changing dosage, you need to be monitored by a health professional (which I'm not, thus take this as one man's views.). Mood changes and the possibility of suicidality aren't something to try to watch for by yourself as you're the one whose judgement is being impacted by them.

Comment: Re:Hooray! (Score 1) 676

by Hartree (#49460227) Attached to: Hillary Clinton Declares 2016 Democratic Presidential Bid

There's been stupid conspiracy theory class criticism of every president I've lived under on every possible point. (Well, I can't remember so much about JFK. I was one year old when he was assassinated.). With Obama, it can be racial, or that he's a muslim or the birther nonsense

But there's also yet to be one that didn't deserve well thought out criticism of policy.

Comment: The NSA Obviously: (Score 1) 443

Just create a web site lauding ISIS (or the little green men in Ukraine, or the North Koreans, etc. There's a long list.).

You're guaranteed to have all your data backed up on the best quality archival storage the US government can find!

Just don't get too over the top. Predator drones, you know. ;)

Comment: Re:Hooray! (Score 1) 676

by Hartree (#49459569) Attached to: Hillary Clinton Declares 2016 Democratic Presidential Bid

"If people consistently think your criticism has racial overtones "

It's certainly not consistently, but has happened. Mostly I've chuckled at how ridiculous it is, or replied: In the words of Bugs Bunny, "What a maroon."

Laughing at misplaced righteous outrage usually works a lot better than replying in kind.


LG's Leather-Clad G4 Revealed In Leaked Images 39

Posted by samzenpus
from the take-a-peek dept.
An anonymous reader writes Evan Blass, known on Twitter as @evleaks, released images of LG's G4 smartphone which was supposed to be unveiled April 28th. "The images reveal what appear to be a multitude of swappable back plates. There are at least six different real leather backs (ranging from black and brown to baby blue and yellow), as well as three more traditional plastic backs. It's fair to assume that the leather versions will carry a cost premium. The LG Quick Circle case, which has a window to let you view notifications while the cover is closed, also appears to be making a return with the G4."

You will have a head crash on your private pack.