Basically, my advice to people who are relatively savvy is not to bother with antivirus. Once antivirus detects anything, it's generally too late. AV can be useful for people who have _no_ clue, but they're bound to get infected anyway sooner or later.
Wrong , if the AV software reacts it's normally because it's actually doing it's job and preventing infection. One or two times a year NOD32 informs me of an infected file and i let it delete it.
At work i often get notifications from Trend Office Scan that a couple of files on some users computer have been infected,detected and deleted.
So in my experience AV software is mandatory
If at first you don't succeed, you are running about average.