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Comment: Noob Intern Replying (Score 1) 136

by Guppy (#48852891) Attached to: Drug Company CEO Blames Drug Industry For Increased Drug Resistance

It is even more interesting to me knowing the first CRE (Carbapenem-resistant Enterobacteriaceae [cdc.gov]) clearly arose in India.

Funny thing was the response of Indian politicians was that naming of the NDM-1 resistance factor was "malicious slander". The acronym of course standing for New Delhi Metallo-beta-lactamase. I happen to agree that geographic and ethnic names should no longer be used for disease entities, but nationalistic outrage is not a useful response to a problem.

but the reasons weren't clear to me and I just naively assumed it was a random mutation. India, also according to to that same paper has quite a problem with antibiotic resistance which one wouldn't expect as there isn't so much of a problem with antibiotic overuse as there seems to be in the West.

Don't be so sure of that, when antibiotics are (or maybe were until recently) common non-prescription OTC products in India and other parts of south and south-east Asia, and often much cheaper than in the West.

Comment: Re:Holy Carp! (Score 5, Interesting) 136

by Guppy (#48852795) Attached to: Drug Company CEO Blames Drug Industry For Increased Drug Resistance

So it's the water coming out of the plant that (sometimes) reaches that level. The actual river has orders of magnitude more flow than that.

So he may have a valid point, but this is obvious FUD.

So in other words, the river itself might have a few tenths or hundredths of a percent of a concentration below the therapeutic MIC (potentially of multiple different antibiotics, depending on what factories happen to be located on that river).

Your interpretation of this is doesn't-matter, therefore FUD. My interpretation of this is enough to exert influence on relative competitiveness within a microbial community, and exert selection for antibiotic resistance.

Long before you reach lethal anti-microbial concentrations, you get subtle changes in growth rate and microbial gene expression. In agriculture, farms routinely use antibiotics at just a few percent of therapeutic dosing, and that is already enough to cause massive changes in the microbial community (with the side-effect of improving the growth rate of the host animal). You don't need to directly kill the microbes themselves, you just need enough to skew the balance of power between the various micro-organisms that are busy competing with each other.

The concentrations in the river may be a fraction below even that, but even slight pressures are enough to alter the course of evolution, when administered over a long enough time period. And "long enough" in this situation is in the context of an organism with 20-minute generation times.

Comment: Gray-market Nintendo smuggling (Score 3, Insightful) 111

by Guppy (#48786379) Attached to: Nintendo Puts Business In Brazil On Hiatus

In a statement e-mailed to Polygon, Nintendo of America said that the company's distributor for Latin America would no longer send products to Brazil, but it would continue to distribute Nintendo goods to other parts of South America.

So in other words, Nintendo's legitimate subsidiary cannot compete with gray-market smugglers who evade the tariff to bring in consoles and games from the neighboring countries.

So they're just going to pull out and let the smugglers be their de-facto distribution channel.

Comment: Re:fixing modern gadget (Score 1) 840

Oh sure - if a tiny grain capacitor without marking is failing - I bet the author can't even de-solder it
find the same part and solder it back on

same with BGA chip - ever try desolder a 400 balls BGA chip in your gadget and try to find that chip in your radio shack?

There are little repair places in China and Hong Kong that will do exactly that. I've heard it's amazing the kind of repairs and mods you can get done in little hole-in-the-wall shops over there.

Comment: Setting up your own VPN? (Score 1) 121

by Guppy (#48732477) Attached to: Netflix Begins Blocking Users Who Bypass Region Locks

So how do I go about setting up a home router with a VPN exit point, for my own personal use while traveling? I've seen some of the various *WRT and other router firmware packages with VPN servers, but I have never managed to get one to work. Couldn't tell if I was messing something up on the router, or on my laptop / mobile phone client, or it was some firewall I was hitting at my hotel or hotspot I was connected to (although my university's VPN usually would usually function properly, so I don't think that was it).

Any cookbook instructions out there that will let me get something working?

Comment: Re:who cares? (Score 4, Insightful) 168

by Guppy (#48589729) Attached to: Airbus Attacked By French Lawmaker For Talking To SpaceX

an idiotic remark that is inconsequential to anything.

Is it? I'm really surprised that Airbus had the chutzpah (or political naivete).

You see, Airbus gets quite a bit of help from the governments of Europe -- subsidies, contracts; I wouldn't be surprised if they had a major hand in the mergers that formed the company in the first place. Most likely, the lawmaker is thinking of Airbus as being little different from some wayward administrative division in his own bureaucracy, now in need of a rebuke for not supporting the government's agenda.

Comment: Re:Diversity is good, especially in SciFi (Score 1) 368

by Guppy (#48543773) Attached to: Overly Familiar Sci-Fi

Hey, you know what else won't be the same? Language!

The Girl-Thing Who Went Out for Sushi would be a good example of a story that pushes that boundary (within the constraints of being able to still communicate with the reader). Not just choosing to invent silly terms for familiar things, but creating a culture-shock effect, where new slang is invented to reflect a new culture.

Comment: Re:Summary of Trailer (Score 1) 390

by Guppy (#48488619) Attached to: First Star War Episode 7 Trailer Released

This seems like canon, I thought all the stormtroopers were clones of Jango Fett

Presumably at some point the clone tanks get blown up, or maybe conscripts ended up being cheaper than clones.

Although it would be more interesting if some random strain of the common flu ended up adapting itself perfectly to that nice monoculture of Fetts, and killed them all off (except for Boba, who got a flu shot).

Comment: Re:Google also has a plan (Score 2) 334

by Guppy (#48437653) Attached to: The EU Has a Plan To Break Up Google

Practically, the EU branch of their offices needs to be little more than a cubicle with a lawyer and desk.

But oddly enough, on paper it seems a huge portion of Google "exists" in the EU, legally speaking. As far as revenues and expenses go, a huge portion of Google's revenues and expenses are "generated" there, (specifically, Ireland), thanks to an international tax dodge.

Comment: Re:Not a surprise, but is it just one ingredient? (Score 4, Interesting) 422

by Guppy (#48182019) Attached to: Soda Pop Damages Your Cells' Telomeres

Sodium benzoate

My money is on the sugar/syrup itself, acting through the insulin-like growth factor system. There is substantial evidence that decreased IGF activity lengthens lifespan and reduces cancer risk, while increased activity drives increased cell-division activity and apoptosis.

Comment: Research Paper Link (Score 5, Informative) 422

by Guppy (#48181999) Attached to: Soda Pop Damages Your Cells' Telomeres

1) What is the name of the paper?

Found it: http://ajph.aphapublications.o...
"Soda and Cell Aging: Associations Between Sugar-Sweetened Beverage Consumption and Leukocyte Telomere Length in Healthy Adults From the National Health and Nutrition Examination Surveys"

Objectives. We tested whether leukocyte telomere length maintenance, which underlies healthy cellular aging, provides a link between sugar-sweetened beverage (SSB) consumption and the risk of cardiometabolic disease.

Methods. We examined cross-sectional associations between the consumption of SSBs, diet soda, and fruit juice and telomere length in a nationally representative sample of healthy adults. The study population included 5309 US adults, aged 20 to 65 years, with no history of diabetes or cardiovascular disease, from the 1999 to 2002 National Health and Nutrition Examination Surveys. Leukocyte telomere length was assayed from DNA specimens. Diet was assessed using 24-hour dietary recalls. Associations were examined using multivariate linear regression for the outcome of log-transformed telomere length.

Results. After adjustment for sociodemographic and health-related characteristics, sugar-sweetened soda consumption was associated with shorter telomeres (b=–0.010; 95% confidence interval [CI]=0.020, 0.001; P=.04). Consumption of 100% fruit juice was marginally associated with longer telomeres (b=0.016; 95% CI=0.000, 0.033; P=.05). No significant associations were observed between consumption of diet sodas or noncarbonated SSBs and telomere length.

Conclusions. Regular consumption of sugar-sweetened sodas might influence metabolic disease development through accelerated cell aging. (Am J Public Health. Published online ahead of print October 16, 2014: e1–e7. doi:10.2105/AJPH.2014.302151)

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