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Comment: Story about a Female ChemEng major (Score 2) 427

males/boy choose masculine jobs/toys (e.g., coding... yes, its "masculine"!) while females/girls choose feminine jobs/toys (e.g., nurses... good for them!)

This is just an anecdote (and thus worthless as data), but I have a family friend -- a female -- who earned a B.S. in chemical engineering. Dad was an engineer, and I think mom was a scientist, so she was highly encouraged (well, pressured) to go in a STEM direction. And she did it, she managed to pass all the math courses and crunch all the equations, earned her degree. And as a newly-minted female Chemical Engineer, I"m guessing a lot of companies were interested in hiring her, as they have been making intense efforts to fix the gender imbalance in their workforces.

Guess what happened next? She then proceeded to go back to Nursing School, and has since graduated and now does clinical nursing work. Basically, she paid four years of hard study and tuition to make other people feel good about make the "right" decisions for someone else's life, and only after satisfying them did she get to live her own life doing what she wanted to do.

Comment: Re:Microshafted to the max (Score 1) 126

by Guppy (#49767563) Attached to: Microsoft Reportedly May Acquire BlackBerry

The Scroogle campaign has not to date done much to Bing the Google thing but it is obvious that the campaign to undermine, defame and absorb them is still alive and screwing over the market place! Milo Minderbinder has nothing on Microsoft!

Microsoft has already switched tactics, recognizing the Scroogle campaign was going nowhere. Currently the main thrust to boost search is through free "Windows with Bing" devices (pairing up with Intel's anti-ARM contra-revenue strategy), and the Android-with-Microsoft ecosystem they are trying to build up through Samsung and Cyanogen.

Comment: Re:And? (Score 3, Informative) 292

by Guppy (#49763427) Attached to: Study: Science Still Seen As a Male Profession

Men can carry a baby to term via embryo implantation and abdominal pregnancy.

This is so insanely dangerous (to both parent and fetus), that any physician who assisted in setting such a thing up would be in danger of having their license yanked. A number of healthy live births have been reported, but most often this special case of ectopic pregnancy ends up being surgically aborted -- because when allowed to proceed the likely scenario is massive hemorrhage followed by demise of the fetus (and maybe the parent too).

That being said, it makes for an interesting thought experiment. You'd probably want to select for a male embryo to implant, as the man's hormones will cause abnormal genitalia in a female infant. You might be able to alleviate this problem with testosterone suppression therapy (after all, females normally have a small amount of circulating testosterone naturally -- but it really doesn't take much excess to virilize a female fetus). What to do about other hormones is also an interesting question -- for instance, how necessary would it be to supplement progesterone, for instance?

Another important issue is the immunological tolerance that occurs in the female, we don't know if males will respond appropriately to with induction of the special partially-suppressed state that occurs during pregnancy. We also don't really know what all the hormones and other substances pumped out by the placenta and fetus would do to the male host.

Comment: Re:Sudafed (Score 1) 333

by Guppy (#49721549) Attached to: Genetically Engineered Yeast Makes It Possible To Brew Morphine

The stuff reproduces itself; all it takes is one well-bribed or entrepreneurial employee.

Indeed. Right now, a spy or disgruntled insider might be able to smuggle out schematics of the factory. Now they can smuggle out the factory itself.

This story from 201 doesn't explicitly state there was any theft of a bio-engineered organism (involved in biotech mass-production of a chemical substrate), but I wonder if something like that might have been involved: http://www.nytimes.com/2011/12...

Comment: Old Man Murray (Score 1) 87

The short demo shows some pretty impressive graphics, with an amazing level of detail. As the camera zooms in, you can clearly see imperfections in the skin, along with glistening effects from areas where the face is wet with either tears or water

The style of the article reminds me of an Old Man Murray new article, featuring a glowing description of the rendering power of the (then not yet released) PS2 (article at bottom of page): Playstation 2 To Usher In New Era Of Underage Girlfriend Simulation

Comment: Social Contract and Emergent Behavior (Score 1) 1081

by Guppy (#49261297) Attached to: How To Execute People In the 21st Century

Here's an alternative interpretation of what the "social contract" is -- civilized society is an example of Emergent Behavior.

It's not a legal rule, where paradoxes of consent or capacity are questions that must be answered. It is simply the rule-set from which the emergent behavior of human society arises, like some cellular automata system. What behavior comes out of the system -- be it a civil society or Lord of the Flies -- is a judgement-free result that depends on the proportion of adherents, versus dysfunctional units and cheaters.

Comment: Car Analogy (Score 1) 77

by Guppy (#49151313) Attached to: Banned Weight-loss Drug Could Combat Liver Disease, Diabetes

DNP is an ATP inhibitor, which means it prevents cell mitochondria from synthesising ATP from simple sugars.

I think I understand what you're trying to say, but let me make it a bit more clear using a car analogy. Yes, you get less ATP out at the end, but that's not really the point of the drug.

DNP is an oxidative phosphorylation decoupler. What this means, it that it does the equivalent of popping your clutch into neutral, and then stomping on the gas. Your mitochondria will rev-up furiously, but no ATP is produced as you have just decoupled the connection between the engine and the wheels. In the meantime, you burn a lot of gas.

Comment: Happened to my grandmother (Score 2) 98

by Guppy (#49145707) Attached to: Fighting Scams Targeting the Elderly With Old-School Tech

Yeah, these scammers tried hitting my grandmother before, fortunately she's still pretty sharp and recognized it immediately.

That being said, with social media, these kinds of scams have the capability to become a lot worse. The scammer that called my grandmother did a generic "grandmom it's me", which didn't work because my Chinese is pretty accented as an American-born speaker -- instant giveaway from the first word out of his mouth.

But with a little research they could have loaded it up with a lot more detail.

Comment: Re:Operating at 20W gives zero improvement. (Score 1) 114

by Guppy (#49124327) Attached to: AMD Unveils Carrizo APU With Excavator Core Architecture

It's knocking out a whole chip, it could bring the price of the whole PC down to less than a couple hundred.

The low end has been sitting at a couple hundred for a while now -- and during that time, the quality of the CPU and GPU you can get have just gotten better and better, to the point that even net-top CPUs can get the job done. I'm amazed at how good even low-end netbook processors are these days.

Comment: Noob Intern Replying (Score 1) 136

by Guppy (#48852891) Attached to: Drug Company CEO Blames Drug Industry For Increased Drug Resistance

It is even more interesting to me knowing the first CRE (Carbapenem-resistant Enterobacteriaceae [cdc.gov]) clearly arose in India.

Funny thing was the response of Indian politicians was that naming of the NDM-1 resistance factor was "malicious slander". The acronym of course standing for New Delhi Metallo-beta-lactamase. I happen to agree that geographic and ethnic names should no longer be used for disease entities, but nationalistic outrage is not a useful response to a problem.

but the reasons weren't clear to me and I just naively assumed it was a random mutation. India, also according to to that same paper has quite a problem with antibiotic resistance which one wouldn't expect as there isn't so much of a problem with antibiotic overuse as there seems to be in the West.

Don't be so sure of that, when antibiotics are (or maybe were until recently) common non-prescription OTC products in India and other parts of south and south-east Asia, and often much cheaper than in the West.

Comment: Re:Holy Carp! (Score 5, Interesting) 136

by Guppy (#48852795) Attached to: Drug Company CEO Blames Drug Industry For Increased Drug Resistance

So it's the water coming out of the plant that (sometimes) reaches that level. The actual river has orders of magnitude more flow than that.

So he may have a valid point, but this is obvious FUD.

So in other words, the river itself might have a few tenths or hundredths of a percent of a concentration below the therapeutic MIC (potentially of multiple different antibiotics, depending on what factories happen to be located on that river).

Your interpretation of this is doesn't-matter, therefore FUD. My interpretation of this is enough to exert influence on relative competitiveness within a microbial community, and exert selection for antibiotic resistance.

Long before you reach lethal anti-microbial concentrations, you get subtle changes in growth rate and microbial gene expression. In agriculture, farms routinely use antibiotics at just a few percent of therapeutic dosing, and that is already enough to cause massive changes in the microbial community (with the side-effect of improving the growth rate of the host animal). You don't need to directly kill the microbes themselves, you just need enough to skew the balance of power between the various micro-organisms that are busy competing with each other.

The concentrations in the river may be a fraction below even that, but even slight pressures are enough to alter the course of evolution, when administered over a long enough time period. And "long enough" in this situation is in the context of an organism with 20-minute generation times.

Like punning, programming is a play on words.

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