A show about factor workers would have those factory workers performing different hijinks at work. There would be different guest stars, but there'd still be guest stars. Different ingredients, same formula. And if you pay attention, many of the jokes only use science references as window dressing, when the real punchline is often something like Raj's inadvertent gay innuendo.
The Big Bang Theory is one of the highest rated shows. It is not a niche show that only appeals to intellectuals because of its sophisticated humor. It is a mass-market show that tries harder than you realize to appeal to a broad base.