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Comment: Re: Wouldn't the new cells have the same diseases? (Score 2) 31

by toppavak (#49763207) Attached to: Nerve Cells Made From Blood Cells
In most cases they would, the thinking is that once you can grown custom neurons outside of the body, you can also modify them to be resistant to or able to reverse the disorder. For example, what if you could re-engineer normal neurons from a patient with Huntington's disease. Injecting them back in, maybe they would replace some of the dying neurons and at least diminish the effects of the disease. If you could engineer glial cells that can properly transport beta-amyloid or are hyper effective at it, maybe they can compensate for cells that can't and slow down the progression of Alzheimer's to push it back beyond reasonable human lifespans. The other key idea is now you have a way of producing cells that carry the disease genes without having to cut open someone's brain to get at them. This is one of the first necessary tools to study and develope new treatments to fight these diseases for which no human-derived models exist. This is probably the likliest short term benefit of such technology (ie benefit in 10-20 years rather than 20-50 year timeframe) accelerating the pace of drug discovery.

Comment: Re:Advertisers reeling over this small fix! (Score 1) 113

by ColaMan (#49371833) Attached to: How Malvertising Abuses Real-Time Bidding On Ad Networks

I'm afraid you're going to have to retire the "HATE THIS" meme.

From now on, you have to write the hooks to ad-laden drivel using the following as a guide:



"He Downloaded Adblock And Installed. When He Reloaded The Page, I Was Amazed."

Ensure That You Capitalise Every Word For Maximum Impact.

Comment: Re:The quality of a lot of that feedback is suspec (Score 1) 236

by ColaMan (#49259799) Attached to: Microsoft Has Received 1 Million Pieces of Feedback For Windows 10

If you buy a blender and it doesn't turn on, you'll take it back to the shop where they'll say things like, "You plugged it in? Locked the jug on top of the base correctly? Pressed this button here?"

"It doesn't print" is a bug report, but it's a report that implies a two-way conversation is going to take place. Perhaps Microsoft should have said in the app, "Hey, put as much info as you can in as to what you were doing at the time, because we can't get back to you once you hit submit."

Comment: Re:What do you mean 'in 10 years'? (Score 4, Insightful) 209

I am not a participant in ANY social media at this point

You don't define slashdot as 'social media'?

But I know you live in the US. You're somewhere in your late 40's. And like to ride bikes. And train on said bikes a lot because you're on a road race team. And that's just the first page of your slashdot comments that I idly flicked through.

I suppose you could tell me that's all part of the plan and that you're actually a dog........

Comment: Re:The research is very interesting (Score 3, Interesting) 61

by toppavak (#49188457) Attached to: Inside the Weird World of 3D Printed Body Parts
Printed parts are still by far inferior to more conventionally produced alternatives. For organs with 3D architecture, by far the most successful approaches have been to basically seed the relevant cell types in layers on a gel or degradable fiber based scaffold. Anthony Atala's group at Wake Forest (no association, just a fan of their work) has made replacement urethras and bladders among many others that have actually been implanted in patients. I believe the bladder work is currently in a phase II clinical trial on its way to becoming more widely available. Sangeeta Bhatia's group has done amazing work on liver tissue, although their focus has been on laboratory samples for drug testing rather than implantation for the time being. They actually do use a 3D printing approach to their work but only to build a sugar-based scaffold that can dissolve away and leave space for blood vessels to be engineered. The tissue itself is just dumped onto the scaffold in a gel slurry and organizes itself.

I think 3D printing tissues is a rather short-sighted approach to assembling structures whose function and shape is self-organized. The most successful approaches thus far (in terms of having products on the market or organs in people) have been strategies that rely on the intrinsic self-organization of tissues. Even more complex structures such as the colonic epithelium can be generated this way.

Any sufficiently advanced technology is indistinguishable from a rigged demo.