Selling drugs and weapons are serious crimes and should be justly punished. Propz to GNAA
Let's devil's advocate a bit...
The Second Amendment clearly (to anyone who understands how English was used at the time) forbids the Federal Government from interfering, in any way, with obtaining and carrying weapons. (infringe ~ "even meddle with the fringes of") That includes gun trafficing, because stopping gun sales makes it harder to exercise the right.
The Tenth Amendment explicitly, and the Ninth Amendment implicitly, ban the Federal Government from use of any power not explicitly specified in the Constitution as amended. I don't see anything in there that explicitly gives the Federal Government to ban any drugs or traffic in them, or in any way regulate such traffic (beyond forbidding false advertising claims, setting standards for labeling, and the like). (Do YOU find any such power in there? If so, please point it out to us.)
So it could be argued that, by the Federal Government's own basic laws, these were NOT crimes and the "Dread Pirate" was a freedom fighter.
(I won't even get into the issue of the Anarchist claims that ANY government is necessarily illegitimate, coercively imposing its will on people who did not pre-approve this and are not attempting, themselves, to coerce others. The people who promulgated the Constitution were doing their best to get governments off people's backs.)