This is all so much saber rattling. Neither should, nor would separate. It is a political ploy fed to citizens in order to negotiate a better deal within respective unions or confederacy. In both cases, should the actual event ever happen they would be screwed in so many ways. Quebec gets preferential treatment to appease them. Every now and then they will threaten, but in the hopes of getting even more preferential treatment.
The last referendum Quebec had, we ran a pool on what the vote would be. That is about how worried the rest of the world is about Quebec actually leaving Canada. Eventually people will get sick of it and call their bluff and say, go ahead then, separate already. It's like the child threatening to call child services on their parents, and the eventual response being, here is the phone, would you like me to dial the number for you?