I can't tell you how many people I know are looking for a LiveCD/DVD that runs Linux (Ubuntu would be preferred just for ease and familiarity for these people that work on Windows machines all day) and has a GOOD antivirus program along with a GOOD or maybe a few anti-malware programs that will scan the local Windows hard drive. Sure, some LiveCD's are out there but it would be great if you could update them on the fly. I know it wouldn't save to the CD, but just updating it in a RAMdisk would be great. Having to update it each time would be fine.
Being able to walk over to an infected machine, boot from a CD/DVD to an Ubuntu desktop and run up to date cleaning utilities from there would be so incredibly helpful.
I've seen people try, but so far all the attempts I've seen... kind of suck.