OTOH, the traditional CPU/mobo setting is a little problematic; first you put the most heat-concentrating element in the middle of everything, and then later you realize it needs cooling.
The theory is that the exhaust air from the CPU heatsink spreads out to parts that are more heat-tolerant but still need active cooling, such as the voltage regulators. A VRM that can operate at 100C without trouble can be cooled just fine with a slow flow of 50C exhaust air from the CPU cooling system.
In practice, people have found that a front-to-back airflow, preferably ducted, is quieter and more effective than a mix of back-to-front, blow-down, and turbulent airflows. It does, however, require actual engineering work, rather than just attaching a bunch of fans to everything.