A couple of ACs have more than adequately responded to this, and should be modded up, but I will give some specifics:
Fine if you're a commercial site and your client knows your job will take 2-3 weeks and cost a few thousand.
No, this is for small in-house things. For things going out, we do a much better job, with real schematic capture and real layout tools.
If you're just looking for a quick fix, there is no 1-day PCB turnaround under $100.
Sure there is (if you allow a day for shipping). I can get 3 pieces of a miniboard from expresspcb.com for $51 + shipping. IIRC, one-day shipping is a bit over $20, so for $75 I can send off a design before 1:00, and have the boards before 1:00 two days later.
If all you need is 1 print and you're a hobbyist or need something one-off, that is unacceptable.
As I said in my initial email, that depends on whether your time is valuable. In my experience, it takes a lot less total time to get a working prototype with a PCB than without, unless your circuit is very small. So if you can wait a couple of days for your circuit, and you have other things to do in the meantime (e.g. your time is valuable) and you'd like to spend less total time on the board (e.g. your time is valuable), then not laying out a board is unacceptable.
Of course, you can do whatever you want. I've seen people dead-bug 176 pin QFNs and make them work. If you find detailed work like that therapeutic, fine. But if you have other stuff to do, it can quickly become cost-ineffective.