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Comment: Mechanism of action (Score 1) 35

by Boghog (#39602093) Attached to: Using Nanoparticles To Improve Chemotherapy
From the article: The nanoparticles are made from cyclodextrins coated with PEG that contain as cargo the anticancer compound camptothecin. The selectivity is apparently not due to the selective uptake of nanoparticles by cancer cells but rather that the interior of cancer cells are more acidic than normal cells. After cells takes up nanoparticles, the nanoparticle breakdown releasing the camptothecin. Because of the lower pH, the break down occurs faster in cancer compared to normal cells.

Comment: Re:How many flase positives? (Score 1) 102

by Boghog (#36865238) Attached to: New Blood Test Can Detect Alzheimers
Currently it is extremely difficult to conduct clinical trials for Alzheimer's Disease (AD) treatments since it takes a long time to determine efficacy. An effective AD biomarker such as this blood test could provide much quicker feedback to tell whether and experimental drug is working or not. See for example: The Role of Biomarkers in Clinical Trials for Alzheimer Disease

Teutonic: Not enough gin.

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