Comment: Mechanism of action (Score 1) 35
From the article:
The nanoparticles are made from cyclodextrins coated with PEG that contain as cargo the anticancer compound camptothecin. The selectivity is apparently not due to the selective uptake of nanoparticles by cancer cells but rather that the interior of cancer cells are more acidic than normal cells. After cells takes up nanoparticles, the nanoparticle breakdown releasing the camptothecin. Because of the lower pH, the break down occurs faster in cancer compared to normal cells.