No it isn't. Absolutely nothing stops ad blockers using heuristics to identify "ad shaped images" or simply having manually written lists of DOM paths to nuke.
I find this whole attitude of "shut up whiners, make your ads EXACTLY meet my unique criteria or else I'll just benefit from your work for free - see if you can stop my nya nya" to be appalling.
Apparently people haven't thought through where this ends. It ends with someone eventually making a non-web content platform that doesn't support ad killers, uses video-game like "anti cheat" techniques and which gets the lions share of the best content because publishers are sick of being ripped off. You know, kind of like how the PC used to be the primary gaming platform in the world and eventually most of the AAA games were coming out on consoles first, and PC maybe or never. Basically, because of piracy and the console makers commitment to fighting it.