Not with a fan that size. and I highly doubt that a HEPA filter and a fan works. you need significant air pressure behind the fan to get any real filtering volume.
Honestly people buying cheap pleated paper furnace filters and doubling them up over their windows will be more effective. when it can filter 50CFM then I'll be impressed. and that will be for a very small one that can barely keep up with air leakage of a tiny apartment.