People don't realize that it is extremely toxic to the liver in anything above a normal dose, and MUCH MUCH moreso if alcohol is involved. If alcohol is involved 1 tablet is enough to send you into liver failure. That said, I get sinus headaches frequently due to allergies, but I only take a half dose of generic excedrin when I get one, and it usually takes care of it right away. That has 250mg of acetaminophen, 250mg of aspirin, and 60mg of caffeine. Supposedly, otherwise healthy individuals who do not consume alcohol can tolerate up to about 4000mg/day (but some researchers disagree and think anything over 1000mg/day is bad). Either way, acetaminophin should be "do not take more than you absolutely need".