I just sold the fact that dgatwood has anal retention issues to Ex-lax.

My eyes are particularly sensitive to bright light and flicker and things like that -- I havent read this study, but I tend to concur as after oodles of tweaking, I have settled on white text on blue background. I have found that not using too many colors (eg. turning off syntax highlighting) helps, and choosing bigger and clearer fonts (dont know how to quantify "clearer"). Refresh rate should be high too. Contrast and brightness should be lower than default. Tend to pick greys instead of whites, eg. rgb=0.9 each instead of 1.