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Comment And the original AC is wrong. (Score 1) 174

What original AC is saying is that our current medicine doesn't resemble Star Trek style ... We drop blanket bombs into our bodies with the expectation that the evil bits will die a whole lot faster than the good bits, and by the time the evil bits are dead, the good bits are still in a good enough shape to regenerate.

No that is NOT what we do for practically anything but chemotherapy for most cancers (where the difference from normal tissue is very small - a few mutations in signaling systems) and the main difference is that being stuck in reproduction mode makes them somewhat less robust.

Antibiotics are all about targeting one or another chemical mechanism that has one form in the target organism when its equivalen has another - or is absent - in human tissue. There are a LOT of drugs that have been discovered or designed, and the collection consists of enormous numbers of "magic bullets" that each target just one, or a small set, of systems found in particular pathogenic lifeforms, with either negligible, or far lower, side-effects on other systems.

Sure many antibiotics hit a wide range of NON-human life - pathogens and others - because THEY share susceptable versions of the target system or contain systems that are strongly side-effected. Sure the doctors sometimes have to pick drugs with bad side-effects because those are the best choices they have. But the characterization of antibiotic and antiviral drugs as "blanket bombing" has been out of date for more than half a century.

Comment Re:Taste like chicken? (Score 1) 107

Recent research has shown that chickens are the closest living relative of T. Rex.

Do you have a reference for the research?

If it's true that T.rex is closer to chickens than to pheasants, peafowl, and other Phasianinae, it would mean that the Phasianinae family dates back to before the K-T disaster.

This was all over the mainstream press last April. I was echoing their over-simplified characterizatoin of the research.

It's actually "closest living relative among the set of genetic databases they tested", I.e. chickens, sheep, etc. Chickens happened to be a bird they tested, with aminno acid sequences far closer to those of the collagen recovered from T. Rex - nearly identical, in fact, than those of things like mammals. So don't expect this to re-write taxonomy - or to mean that chickens were any closer - or farter - from T. Rex than their close relatives such as phesants.

Of course there's other evidence that birds were around well before T. Rex. So it may turn out that chickens are closer relatives to T. Rex than, say, bluebirds. (Or maybe bluebirds will turn out to be closer, once they're compared.)

Comment Re:my solution is the gym (Score 1) 819

I win more times than not and the jackass in front of me gets a sore back for their troubles.

I'll be the jackass complaining to the flight attendant in the sweetest manner possible that the passenger behind me is intentionally burying his knees into the seatback.

With your attitude, you'll be the jackass having a conversation with the air marshalls after backtalking the flight attendant while desperately trying to explain why your knees absolutely must be placed right there.

Winning...

Comment Exactly. (Score 4, Informative) 55

... give the patient more time to produce his own antibodies. ... the experimental treatment used on some western patients is basically antibodies.

Right on both counts.

  - Much of why Ebola is so often fatal is that it produces a glycoprotein that interferes with immune system signaling, reducing and delaying the immune system's antibody-mediated specific responses. (Meanwhile the cell damage and foreign protein stimulate the GENERAL responses, which causes self-damage to the body and aids in spreading the infection.) Details on Wikipedia Keeping the virus population and the glycoprotien concentration down by supplying ready-to-go antibodies holds down cell death from infection, self-destruction, and signaliing interference, giving the immune system more time and ability to respond.

  - The drug in question is a mix of three monoclonal antibodies, manufactured by stock genetic engineering techniques.

Injections of extracted antibodies, or blood containing them, has a long history in medicine. They have been used against bacteria, viruses, and poisons such as snake venom. Typically they are made by extracting a blood fraction containing antibodies from an animal which has been recently immunized - and is currently hyper-reactive to - the target disease agent or venom. (This gets a load of mixed antibodies which is heavy with those specific to the target.) They may also be extracted from a human survivor of a disease of interest, or a human in general. (These you might hear being called "human imune globin" or "gamma globulin".)

Downsides include allergic reactions to the animal used (typically a horse) or person providing the globulin, infection with blood-borne diseases (such as Hepatitis C), and reaction against the patient by some antibody in the serum.

Antiseura fell out of use for bacteria with the rise of antibiotics (even for diseases, such as menningitis, where antiseurm treatment had higher success rates). Antiviral drugs and the rise of a number of human viral diseases are pushing it down in preference for viral disease treatments - though better blood tests for viral infections is improving its safety. Nothing, of course, has replaced it for antivenom. It's still used for things like Hepatitis A, Measles, rabies exposure, supplement for certain immune difficiencies, and modulating immune system rejection of liver transplants.

With both the rise of antibiotic and antiviral drug resistance and the development of monoclonal antibody culture (prodcing just the desired antibodies to a target on an industrial scale, with negligible risk of dangerous contamination), expect more use of antiseura in medicine - like this "new experimental ebola drug".

Meanwhile, using antibodies extracted from ebola survivors - or transfusions if a matching donor is available - is the same system and might work just fine. And the technology is simple and cheap enough to be available even in third world countries.

Of course you need to wait until the survivor has recovered enough to have built up antibodies and enough blood to spare. Ideally you should also wait until the virus has cleared. (For instance, with Ebola, semen remains infective for at least two months, so blood likely does. as well.) But if the patient is already infected and likely to die without treatment, that's not an issue.

Comment Re:Here come the Samsung fanboys... (Score 1) 110

That only applies where the patent owner is the one selling the item, which is not what we are talking about here - check out the following line from that Wikipedia article:

A patent gives the patent owner the right to exclude others from making, using, selling, offering for sale, or importing into the U.S. the patented invention during the term of the patent

See the emphasis I have added.

Where a patented item is being sold by a third party to another third party, no exhaustion of rights exists - both parties are liable because both parties are individually breaching the patent holders rights.

Comment Re:Where are these photos? (Score 1) 336

There is no such thing as a "convicted monopolist", convictions only happen in criminal courts.

And as including the web browser in the OS formed the very basis of the anti-trust action, my point stands - some people would prefer that Windows would come unable to handle the web out of the box, so why should photos be more important?

Comment Misleading wording. This is not autoplay. (Score 2) 131

What the article is referring to as "autoplay" is actually preloading.

Odd... because FaceBook calls it "auto-play." Right in the obscure setting in their own app that admittedly allows it to be turned off or set to Wi-Fi only.

The video is not playing on its own, it's just being cached in case you want to click on it.

Odd... because the videos in the newsfeed will play without anyone clicking on them. You merely have to scroll through the newsfeed and land near a video.

This could certainly be a problem for people on limited data plans.

Which are the majority... it's well known that you have to have truly worked to keep a grandfathered unlimited data plan since the 3G-4G transition.

It is not nearly the same kind of awfulness as genuine autoplay, where the video starts up without asking permission.

Since you appear to have no actual experience with the FaceBook mobile app, you'll forgive me for telling you to STFU concerning the relative awfulness of your fictional app versus the actual app. I mean really... you were so certain of how the current app functions that you thought nobody who actually used it would call you out on these 'minor' discrepancies?

Comment Re:The obvious solution... (Score 2) 63

That's different. That's open-and-shut libel, which yelp is liable for publishing.

...which yelp is not liable for publishing, since the very summary that you supposedly read points out that "Section 230 of the Communications Decency Act (CDA) protects online service providers from liability and lawsuits over user-generated content, except in very narrow circumstances where the providers created or developed content themselves."

(Not a lawyer, though).

Which explains why your conclusion is exactly the opposite of the one required by 47 U.S.C. 230. You'll note that the plaintiffs in this case claimed that Yelp authored or co-authored the reviews instead of merely publishing the reviews. That's because claiming Yelp was liable for simple selection and publishing would be so wrong that it'd likely draw a sanction by the court.

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