I'd characterize that as largely true with one notable exception - the second DLC pack (The Pitt) offered a pretty ambiguous moral choice that didn't result in positive or negative karma for either of the two main possible outcomes. The choice was definitely not clear-cut, and contained lots of room for interpretation as to what the morally "better" choice was.
I have been sitting and working on programming while watching a friend play that content for the first time, and he sat in the pause screen for a good ten minutes thinking about all of the outcomes. Even after he had decided, he felt guilty about the choice he made. Upon discussion, he said he also would have felt guilty but for different reasons for the other choice.
You're largely right, but not categorically so.