I live in the pro audio world, almost at the bleeding edge of it I might add. What the other poster stated about sub 5ms latency is true. Get yourself an HDX system and test it out. Also, there's this, this, the entire Apollo line, and even an entry level interface that's Thunderbolt based.
IMHO, nothing will compare to using a mixer, but that's for the functionality and quality. I would never pitch a Mackie as a decent recording system, live sound, sure, but, unless you've got an Onyx, it's crap for recording (and even then, just decent). A mixer to me is something like this. My interface is a Fireface 800 and I have 0 perceived latency (so long as I'm not sending anything into the DAW for processing on my cue mix, or merely playing back from the DAW and recording new tracks). To claim something as 0 latency would be incorrect for everything, there will be latency. To claim that the conversion process adds less than X ms of latency is what we're talking about, and the Thunderbolt stuff from MOTU (not even a stellar name in the industry) is leaps and bounds beyond my Fireface (it should be, my interface is 8 years old now), clocking in at sub 1ms at the hardware itself (seen in info note in the link above), with the Fireface being a respectable 5ms at the lowest.
Long story short, if you're looking for the lowest latency and a professional setup, Thunderbolt or PCIe is king. If, as it seems from the photo you posted, you're working in a prosumer or entry level situation, than USB will suffice.
(Other sources: I work in pro audio. A number of years of experience behind the board in both live and recording environments on everything from small projects to working with the likes of Bob Mintzer. Much of my knowledge comes from the real world.)