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Comment Dont bank on it yet -- GSK did (Score 1) 34

The lead author, David Sinclair, has pursued some very interesting hypothesis. This work dovetails into his findings about resveratrol. The trouble is that there has been a mixed record, to say the least, in others (Amgen and Pfizer) reproducing his work:
Still you never know, so I'm mixing up a nice resveratrol NAD+ cocktail.

Comment Re:Disciplined Minds in a Big Crunch (Score 1) 308

This thread has to do with Physics. I have a graph I keep around showing how federal funds have been allocated to research by discipline over time. We've been in an age of biology since the late 1970's. But, the same pressures and day of reckoning are at hand. The trouble with physics is, of course, it did its job too well. All the "practical" problems were "solved" ages ago and got spun off to engineering. So too is it with biology research. Eventually the public, and political funders, will wake up and realize there's been almost no advances in say cancer outcome (word chosen carefully) in decades. The basic monies will dry up.

And by the way, the postdoc system should be decried as what it is, a legal system of cross national bondage, and abolished. It should be replaced by a system of contract research, the salaries made competitive with the market, and about half the Ph.D. programs in the country shut down.

Even black holes eventually end.

Comment Old Codger Reveals All (Score 5, Insightful) 617

You reap what you sow...and what the record companies sowed were generations of unsophisticated listeners that don't know the difference between the popular artists and their next door neighbor and his robot. Musicianship, composition, pshaw. Drum machines and stored samples.
I don't care at all, there's plenty of vibrant and new alternative music -- that being jazz and classical and what's out in the World. Just look.

Comment Last of the old ones (Score 1) 57

Golden Ages end. With Pohl it was his skills as an editor. Pick up any issue of Galaxy Magazine in the 60's and you'll be drawn into how well the thing is put together; and how good the writing is. If you like the Sci Fi genre there really is (current tense intended) no better way to read compelling and idea laden works from new and old writers. And like others from the era, his own novels became interesting rather late. "Gateway" is pretty good. The tropes are compelling. But again, Golden ages end.

Comment You can get food from algae (Score 1) 90

Whenever algae comes up I like to cite a noted expert from the area for 50 years:
Benneman
Look the main problem with algae is that it is really a new form of agriculture. And everything people tout as an advantage cuts the other way. At best it is carbon neutral. Now tell me how many desert ponds are located by a source of CO2?
Don't get me wrong, I think Solazyme has nailed it, there are a lot of great things we can do with algae. It can be a food for example; chemical feedstock.
As a fuel...for the infrastructure of ruining vast desert landscapes we'd do far better pumping coal gas CO2 back into salt mines.

Comment Read Jack Vance Aloud (Score 2) 83

His books are so very very well written. And when it comes to colors and places and properly placed latinate adjectives that leave you scrambling for your dictionary, there are few better. And the most important thing to know about Jack Vance is that he recognized the most alien of places is the construct of human culture.
I can't imagine even one of his books made properly into a movie unless Punctilio becomes trendy.
To the outsider go pick up any of his books on E-bay, pour yourself a glass of wine by a cozy fire, and let yourself go. How about "The Last Castle" as a start.
And so funny...

Comment The feel good hit of the summer (Score 1) 1706

My 2 cents on this thing is the danger of those trend setting Coloradans...Columbine set off a worldwide wave of copycat carnage and mayhem; the novel angle
here is the overt targeting of "entertainment". You reap what you sow; did the comicCon culture inadvertently create misfit class of individual who identify with the Super Villain? The promotional campaign for "Batman" now IS the promotional campaign for these violent and evil acts.

I kind of wish Frank Miller had never made Daredevil cool.

Comment Open Access Closed Access -- Give me an RO1 (Score -1) 116

Forgive my wrath, nothing personal, this is science.
"Cell Free" -- are you kidding me -- in vitro? Readit. I have thirty more papers just like it stored in my, "I may write a grant on this someday" folder.
Wikipedia guided me to this one -- not fancy PNAS -- also open BMC veterinary research [1746-6148] Konold (2008 recent) volume: 4 issue: 1 page: 14
Scrapie OPD (Original Prion Disease) Bunch of Sheep, some have Scrapie, PrPd positive. Biosafety 4 (who cleans up the manure). The mama sheep (who go by the scientific term of Ewes) are observed to pass on scrapie to their lambs through their milk. Alright. They didn't separate the lambs receiving scrapie milk from the nulls other and then
"A subsequent sample collected from control lambs revealed PrPd accumulation in two of five lambs eight months after mixing with scrapie milk recipients suggestive of an early stage of infection via lateral transmission." Oops! Boy that scrapie milk sure travels. Please give these guys more money to set some better controls. Virus ahoy my hearties!

Comment Prions: Bunch of Hooey (Score 1, Interesting) 116

Wow. Those genetically modified mice "tga20 transgenic mice overexpressing PrPC" bred to be hyper-susceptible seem to be highly susceptible. After 15+ years of this "ice 9" business I'm still waiting for results that in any way meet Koch's Postulates. Oh yeah, let's stop calling this protein "prion" and start calling it a proteinaceous "toxin" which is what it is. Moreover, since this Nobel Prize winning hypothesis in no way seems to conform with the reality of widely spreading communicable encephalitis in sheep, beef and mule deer why not entertain the notion that this is a slow virus and that the symptomatic misfolded protein is a mere phenotype, possibly detrimental, but not causal. Oh yeah, figuring this out would mean working with big smelly farm animals and we prion people don't like to get dirty.
Meanwhile Laura Manuelidis is fighting the good fight against overwhelming odds.
http://en.wikipedia.org/wiki/Laura_Manuelidis

Comment Net Google Carbon effect (Score 1) 129

But what about Good Google? How much carbon is saved each year, for example, by their handy maps? (Now if I could only get my wife to stop printing them out and just write the directions on a piece of waste paper) How much does Google reduce carbon by efficiently locating points of interest -- and someday -- helping you get your car to the nearest electrical outlet. Sniping at rich people's yachts is I guess a family tradition but the real problem with carbon hypocracy stories is they really don't take in the big picture. I'm for an all electric civilization; wave, wind, sun and nuke. Google is an extremely valuable part of that as it makes things smarter. They can keep their yachts and hovercraft and jet planes.

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