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Comment Re:"Generalized Life" (Score 1) 221

Generalization on the very basic level has also been applied to the definition of life. In my opinion one of the best definitions of life boils down to defining life as a dynamic system which increases and maintains its order in expense of increasing the entropy of its surroundings. Needless to say this definition was put forward by physicists (Bolzman, Schrodinger). Biologist would probably like to add ability to reproduce and evolve, but I don't think this is fair. A mule is a life form, right?

Comment If there ever was a nebulous article... (Score 3, Informative) 221

The original article is pure speculation. Can life exist that is so different from the stuff we know, so that we can't detect it with current molecular biology techniques?

Sure why not. What the article fails to mention is that we can find life in other ways. Even if we can't sequence the DNA in many cases we can culture microorganisms from environmental samples. We can also use microscopy to directly examine environmental samples. In fact both the microbial cultures and microscope have been done on large scale over many years. Not once have we seen an organism that does not conform to our current understanding of life on earth. Life can also be identified by the changes in the environment it create. Again nothing we have seen so far has suggested that there is a life form so unusual that we can't detect it with our current techniques.

Where authors of the original article fail most miserably is their solution: high throughput sequencing techniques. Huh? How would those techniques lead to the discovery of life that is fundamentally different if they are dependent on the standard properties of DNA and DNA replicating enzymes??

Comment Re:Just what any parent knows (Score 1) 154

No, I want a citation(s) for the sources in which the statements that

Everyone is exactly as intelligent as a human, unless they're brain damaged by disease or defect. Any child, any adult, properly motivated, with proper practice and effort, can be a genius.

have been proven to be true.

Comment Re:Just what any parent knows (Score 1) 154

Everyone is exactly as intelligent as a human, unless they're brain damaged by disease or defect. Any child, any adult, properly motivated, with proper practice and effort, can be a genius. It is just that simple.

Citation please

The rest of your post describes how memorization works. Are you implying that intelligence is the ability to reproduce facts, rather than the ability to process information and derive abstract representations?

Comment The perverse incentives in biomedical research (Score 2) 167

My experience is that most of the work is done by the first one or two authors under the direct supervision of the last author (there are exceptions when the lab is very big and the PI has delegated most of the supervision to postdocs or staff). Generally, the corresponding author on the paper bears much of the responsibility for the data being published under the assumption that he is supervising the research and is intimately involved in analyzing the results and writing the paper. Many journals now require a statement, which briefly outlines the authors contributions. Having said that it is not unheard of that a student or a postdoc will manipulate data and the PI in his willingness to prove a hypothesis will not be overly critical.

The deeper problem is that there is a huge pressure in the biomedical field to publish often. The PI will not be able to receive grants unless he/she has demonstrated a track record of productivity. If he/she doesn't get grant funding he/she will not be receiving full salary and will not get tenure. At the same time the competition for funding is furious. The percent of applications being funded by NIH are in the low teens and for some NIH institutes they are under 10%. So not only you have to publish, but you have to publish more and in better journals than 90% of the people in the field to be competitive. All this puts huge pressure on the PIs to publish. Few of them publish rubbish and some resort to fraud. Students and postdocs are under similar pressure to be "productive" not only from their PIs, but also because their future prospects depend on the research they publish.

The irony is that the current situation is to a large degree caused by the expansion of the NIH budget in the past. Public and private research institutions rushed to build lab space, recruit scientist and train students to take advantage of the NIH grants (this expansion still continues!). The incentive for the institutions is that they get 40% or more (up to 100%) on top of the grant award as an overhead. So a typical $250K per year grant from NIH will pay directly to the university at least $100K per year in overhead in addition to sponsoring the PI and staff salaries from the direct costs. The NIH budget, however, did not continue to grow rapidly after the initial jump during president Clinton's time in office and has actually shrunk in the past year. The result is that now you have a large number of scientist desperate for grant money and not enough grants to fund even a small fraction of them. The current incentives do not reward the quality of the research, but the speed by which it is done and its quantity. This is a very perverse situation. It also creates a negative feedback loop where the poor quality of the published data prevents people from defining valid hypotheses or identifying viable lines of research. As a result they waste time and are subject to even more pressure to publish junk.

Comment Re:His articles on PubPeer (Score 1) 167

I don't see any evidence that all the comments are posted from the same person. "Peer 1" is not a nickname or user ID. It looks like the initiator of each thread on PubPeer is automatically named "Peer 1" if he/she is registered. The next commenter on the thread will be "Peer 2" and so on. I also don't see anything personal in the comment that you cite. To me it looks like a statement of fact.

Comment Re:Know who to sue (Score 1) 167

The scientist and his lawyer suspect foul play by anonymous person(s) who allegedly defamed him by posting ad hominem attacks in their pubpeer comments and then distributed those comment pages to both universities associated with him.

Any criticism of his work should be valid and fact based and that should be enforced by the site's moderators.

I am reading through the comments related to his papers on pubpeer. I haven't found any personal attacks. May be there are some in the comments I have not read yet. However, what I find is a number of papers with blatantly manipulated images, use of the same image to represent different experiments in different papers and even a combination of the two. His defamation lawsuit has no legs and the university has every right to rescind its offer. In fact they would have been complicit if they did not do so. I predict that Dr. Sarkar's next discovery will be the Streisand effect.

Comment Re:Russia is back to totalitarism (Score 3, Insightful) 205

Actually, the biggest impact of sanctions has been European farmers.

They tried to bypass sanction by selling to Austria, who would then sell on to Russia. The Russians spotting the scam denied entry (Austria is not known for producing oranges).

The farmers were compensated by the EU. But rather than give the food to some needy Greeks, the food was destroyed.

Quick geography lesson. Austria is in Europe (smack in the middle of it) and is part of the European Union. So your statement that somebody tried to go around the Russian food import ban by going through Austria is highly suspect. The way it is actually done is to go through Belarus. Russia is now importing beef from Belarus, which coincidentally is importing cattle from EU (technically the beef is produced in Belarus, as this is the place the cattle gets chopped up). Somewhat more absurd is the sudden appearance in Russian stores of shrimps originating from Belarus (Belarus is a land locked country). So yeah, if there is a ban there will always be somebody to make money by going around them. The thing is that the Russians will be the ones paying the bill.

Comment Re:So? Old news. (Score 1) 53

The "drug" is based on siRNA which means that it has to be exactly matched to the virus RNA sequence, it uses a sophisticated delivery system (liposomes I gather) and needs storage infrastructure (deep freezers capable of maintaining -80C for long term storage). Considering all of the above, it is a safe bet that mostly rich white people can afford the luxury.

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