About 5 minutes of googling found me vast numbers of things, from laptop locks impervious to the toilet paper tube solution, to locking shelves instead of drawers, to a bar style locking device IIRC I've seen used at CompUSA. Large numbers of people have his issue as evidenced by the large number of solutions available.

My suspicion is that the poster really kinda wants his office back and is making excuses. If this is the case it is natural that no solution is going to work.