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Biotech

Training an Immune System To Kill Cancer: a Universal Strategy 201

New submitter Guppy writes "A previous story reported widely in the media, and appearing both on Slashdot and XKCD, described a novel cancer treatment, in which a patient's own T-cells were modified using an HIV-derived vector to recognize and kill leukemia cells. In a follow-up publication (PDF), a further development is described which allows for a nearly unlimited choice of target antigens, broadening the types of malignancies potentially treatable with the technique (abstract)."

Comment Re:Really? (Score 1) 186

Nice calculations, but they ignore two facts: 1 - the LightSquared frequency is actually pretty far from the GPS frequency (10s of MHz), so the filtering challenge is not as bad as you make it out to be. 2 - Military spec GPS devices have no problems nor do they suffer reduced sensitivity, if someone is already doing it then it definitely can be done.

Comment Re:Corruption. (Score 1) 153

More like 15x to 30x expensive. Aerial fiber runs $3 to $7 a foot, underground is $80 to $150 a foot. Renting existing duct is somewhere in between but generally closer to the underground cost. Underground ducts tend to be in bad shape and require lots of repair work. By the time you complete it your total cost ends up less then digging new but much more than an aerial run.

I have done work installing fiber plant. It isn't easy, seldom quick, and very expensive. You soon discover that there are dozens of petty city bureaucrats who want you to grovel before their awesomeness before they will let you proceed. Even the most beneficial projects garner objections from NIMBYs who are convinced that having a pencil-thick fiber optic cable pass their house will be the End of Civilization. I could go on, but to say the least my experience has greatly reduced my annoyance at the high cost of cable. Every government agency has their proboscis in the wallet of a fixed plant operator looking to suck up funds for their department.

Comment Re:Tuition math lesson (Score 1) 359

There have not been any significant cuts in funding at any level. The issue is that the funding has not risen as fast as college expenditures so that a much smaller percentage of the cost is born by students in the form of tuition. See this link for more details (http://www.highereducation.org/reports/losing_ground/ar2.shtml). It is very common to hear people decrying 'cuts' when there is no such thing going on. The issue is purely one of uncontrolled rising costs full stop.

You are perfectly correct that the extra money is not spent on faculty salary costs. In fact, overall costs for faculty have been slightly declining due to the widespread use of adjunct professors who make very little and have no benefits. So if prices are rising much faster then inflation and the money isn't going to the average professor where is it going?

My guess is campus upgrades (somewhat offset by donations), administration salaries, sports - all of which have been growing like gangbusters at nearly any university you observe. At big universities the sports programs may actually be money-makers, but smaller universities loose money on them. It is also worth noting the rise of 'superstar' professors that make salaries well into the six figures (200k to 400k) and are especially prevalent in law schools.

Comment Re:Other Motivation? (Score 2) 101

Mod this comment up, it is spot-on.

If you follow the wireless industry for a while you see this is a repeat pattern: "Hmm, no one is using the spectrum near what my device will use so I can save a few cents by leaving out the receive filter!"

Garmin has been caught with their pants down and has been desperately trying to spin this as being LightSquared's fault.

Comment Re:A Phone and Android is not enough (Score 1) 240

Mod this comment up. Even if HTC became the dominate Android manufacturer Google would still be cherry picking the profits through their control of the Android app store.

WebOS is a very nice platform with an reasonable selection of *good* apps (1,500 apps might not sound like much compared to 50,000 but if the 1,500 include most of the very popular options you can still have a great experience). The Palm hardware was terrible - always a year behind what the rest of the industry was selling. HTC makes solid cutting edge hardware. I would love to run WebOS on a phone as well built as my EVO 3D.

Comment Re:It's like a religion (Score 1) 668

Posted again because Slashdot didn't give me the opportunity to log in before posting like it used to do...

I find it ironic that those who are most critical of Dr. Wakefield seldom actually understand the claims he made. It is also puzzling to observe how many 'Wakefield has been debunked!' statements are trumpeted about studies that don't even evaluate his specific claims. To be clear, Wakefield postulated two separate but related theories regarding the MMR vaccine and autism:

1 - The MMR vaccine increases the incidence of severe gastrointestinal disorders in very young children.

2 - Severe gastrointestinal disorders in very young children (2.5yrs) increase the likelyhood that they will develop an autistic disorder.

Autism is a spectrum of symptoms, not a specific disease. We do not know what causes it, and it may well be influenced by a variety of different causes. Claiming to have discovered one possible cause does not automatically mean that every, or perhaps even most, cases were related to the identified cause. I read through the section of the NAP book that addresses the issue of MMR and autism and they completely fail to discuss the Wakefield's actual theories. In fact, they even mention to two studies (not by Wakefield) that show a link between MMR and gastrointestinal disorders (theory 1) but make no attempt to discuss or evaluate the second theory. Whatever Wakefield's failings the fact remains that his first theory has independent corroborating evidence and his second theory has never been evaluated independently. The tar-and-feathering he received will insure that the second theory will not be seriously evaluated for a very long time.

It is entirely possible that Wakefield's theory is correct for some subset, perhaps as small as 1%-5%, of the existing autistic population. Anyone who has read about autism will have encountered the stories of children who had both gastrointestinal problems and autism and improved when eating very strict diets (no dairy, gluten, bananas, etc). These cases represent a very small subset of the total population and their risk factor may well have been much higher from the MMR vaccine then the average population. The overall risk of MMR may be too small to detect in the general population but still be fairly high for the specific subgroup that has a family history of gastrointestinal issues.

What do I take from this? Well my wife and her family have a history of gastrointestinal problems. We decided that in light of the evidence that MMR increases the onset of gastrointestinal disorders in very young children that the risk was not worth taking. Instead, we had our daughter vaccinated for each of the three diseases independently when she was five (the Measles vaccine by itself has not been associated with increased gastrointestinal distorders). This was not a 'religious' response, it was a carefully-reasoned and appropriate measure based on the available evidence.

What is truly bordering on religious (and not in a good way) is the passionate and shrill denouncement of this very reasonable and evidence based theory due to the fear that it will be misunderstood by the general population. The truth is still the truth even if you put your fingers in your ears and shout 'la la la I can't hear you!' at the top of your lungs when someone speaks it.

Idiot.

Comment Probably fine (Score 4, Informative) 791

I am a PE and have done hundreds of RF emissions studies on wireless facilities, including rooftop installations like the one you describe. My initial thought is that twenty feet would be an unusually small distance between the antennas and your window. It may very well be much larger then that (50' or more is more likely - and would have much lower emission levels) but seems closer due to the perspective of the surrounding panoramic view. If it were truly only 20', and the building hosted antenna arrays from many wireless carriers (and FM transmitters), then there is a very slight possibility that the levels in your apartment could be near the public exposure limit. This situation is quite unlikely however. Most wireless carriers have an independent RF emissions study performed on rooftop installations that include measurements of the pre-existing antennas, so if you reached the right person and were persuasive enough you might be able to get them to share that with you (very unlikely). Another poster recommended a cheap meter. I'm not convinced of their accuracy, but you could give it a try if it worries you. Someone else mentioned low-E glass and correctly stated that it blocks a significant amount of RF energy. If you have low-e glass then even 20' away would mean your apartment is below the public exposure limit.
Transportation

Compressed-Air Car Nears Trial 173

DeviceGuru writes "Air France and KLM have announced plans to conduct a six-month trial of a new zero-emission, compressed-air powered vehicle. The AirPod seats three, can do 28 mph, and goes about 135 miles on a tank of compressed air. Motor Development International, the vehicle's developer, expects the AirPod to reach production by mid-2009, and to sell for around 6,000 Euro. Initially, it will be manufactured in India by Tata Motors, and distributed in France and India."
Portables

Submission + - Nanotech + battery = 10X performance (news.com)

UNIMurph writes: Stanford University researchers have discovered a way to increase battery life tenfold by using silicon nanowires.

From the article:
"It's not a small improvement," Cui said. "It's a revolutionary development."
Citing a research paper they wrote, published in Nature Nanotechnology, Cui said the increased battery capacity was made possible though a new type of anode that utilizes silicon nanowires. Traditional lithium ion batteries use graphite as the anode. This limits the amount of lithium — which holds the charge — that can be held in the anode, and it therefore limits battery life.

The only problem i can see with this is forgetting to charge the devices that contain them. I already forget to charge my phone due to the battery lasting so long.

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