I am honestly torn on the idea of CSS sprites. While yes, they do decrease the number of HTTP requests, they increase the complexity of maintaining the site. Recently, Vladimir VukiÄeviÄ pointed out how a CSS sprite could use up to 75MB of RAM to display. One could argue that a 1299x15,000 PNG is quite a pain, but in my experience sprites end up being pretty damned wide (or long) if you have images that will need to be repeated or are using a faux columns technique.
Some times it gets to be a better idea to make a few extra initial requests, then configure your server to send out those images with a far future expires header (which you should do for the sprite anyway). At that point you're just talking about the initial page request, and then subsequent visits get the smaller sized. With one site I am working on the initial page view is hitting 265 KB on the initial view, 4.75 KB for the next month.
I don't see this mentioned anywhere, but Google has already switched to the HTML5 Doctype. It is much shorter the other flavors.